How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?

JO Davidson, V Draghi, S Whitham… - Journal of Cerebral …, 2018 - journals.sagepub.com
… directly assessed outcomes against extended cooling for 72 h. … Cooling was started 3 h after
reperfusion and continued until 48 … suppressed until the onset of a period of intense seizure

[HTML][HTML] Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep

V Draghi, G Wassink, KQ Zhou, L Bennet, AJ Gunn… - Scientific Reports, 2019 - nature.com
Cooling was initiated 3 hours after the end of occlusion by … might lead to hypotension or
rebound seizures 20,21 , and … term fetal sheep was associated with partial neuroprotection in …

Endogenous neuroprotection after perinatal hypoxia-ischaemia: the resilient developing brain

JO Davidson, SK Dhillon, G Wassink… - Journal of the Royal …, 2019 - Taylor & Francis
… cell swelling and secondary seizures and ultimately cell death. … Neuroprotection with delayed,
prolonged head cooling after … In preterm fetal sheep, treatment with a prolonged infusion of …

[PDF][PDF] Perinatal brain injury: mechanisms and therapeutic approaches

JO Davidson, JM Dean, M Fraser… - Front Biosci …, 2018 - article.imrpress.com
… can attenuate seizures but show limited neuroprotection. By … , in preterm fetal sheep, dizocilpine
infusion started shortly … factor-1 reduces postischemic white matter injury in fetal sheep. J …

The mechanisms and treatment of perinatal asphyxial encephalopathy

G Wassink - 2017 - researchspace.auckland.ac.nz
seizures, consistent with earlier onset of neural damage. … in preterm fetal sheep was
partially neuroprotective and … plus head cooling did not augment hypothermic neuroprotection

Selective head cooling during neonatal seizures prevents postictal cerebral vascular dysfunction without reducing epileptiform activity

M Harsono, M Pourcyrous, EJ Jolly… - American Journal …, 2016 - journals.physiology.org
neuroprotection of the neonatal brain that prevents long-term … In preterm fetal sheep,
head cooling suppressed early … 2 h in our studies), and acute postischemic (1 h) vs. delayed …

Preterm brain injury: mechanisms and neuroprotective treatments

S Dhillon - 2019 - researchspace.auckland.ac.nz
… during post-HI seizures restricted cerebral blood flow, but … the conversations starting
with “I found something cool today … of rEPO in preterm fetal sheep and preterm infants ...........................…

[HTML][HTML] Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?

A Davies, G Wassink, L Bennet, AJ Gunn… - Neural regeneration …, 2019 - journals.lww.com
… in determining neuroprotection. In near-term fetal sheep, a reduction in brain temperature
from 39.5C … The seizures stopped within 30 minutes of re-cooling the neonate to 33.5C without …

Management of Hypoxic-Ischemic Encephalopathy Using Therapeutic Hypothermia

JO Davidson, AJ Gunn - Principles of Neonatology, 2024 - Elsevier
… In near-term fetal sheep, for example, intense seizures are seen … cooling is delayed until
6 hours in both adult rodents and fetal sheep, greater functional and histologic neuroprotection

Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy

G Wassink, JO Davidson, SK Dhillon, K Zhou… - Current neurology and …, 2019 - Springer
… of epilepsy at 2 years of age compared with the original coolingfetal sheep showed that
neuroprotection with cooling started … death and sterile post-ischemic inflammation augment cell …