The ameliorative effect of nanoselenium on histopathological and biochemical alterations induced by melamine toxicity on the brain of adult male albino rats

DW Bashir, MM Rashad, YH Ahmed, EA Drweesh… - Neurotoxicology, 2021 - Elsevier
… related genes Nrf2 (nuclear factor erythroid 2–related factor 2) and GPx (glutathione … In
conclusion, SeNPs have an ameliorative effect against melamine-induced neurotoxicity

Molecular mechanisms of pesticides toxicity

L Marutescu, MC Chifiriuc - New Pesticides and Soil Sensors, 2017 - Elsevier
… to excitatory amino acid toxins, such as the marine toxin domoic acid. … DNA lesions and
glutathione depletion in mammalian cells. … and neurotoxicity revealed that NCX3 genetic deletion …

Reformulating pro-oxidant microglia in neurodegeneration

J García-Revilla, IM Alonso-Bellido… - Journal of Clinical …, 2019 - mdpi.com
… such as glutathione (GSH), uric acid, … of genes related to the inflammatory response. The
use of sodium butyrate mitigates microglia-mediated neurotoxicity upon middle cerebral artery …

Gut microbiome: an intermediary to neurotoxicity

JL Dempsey, M Little, JY Cui - Neurotoxicology, 2019 - Elsevier
There is growing recognition that the gut microbiome is an important regulator for neurological
functions. This review provides a summary on the role of gut microbiota in various …

Excitotoxicity

MP Mattson - Neurodegeneration, 2017 - Wiley Online Library
… Investigations identified the cause as domoic acid, a potent … activities of catalase and
glutathione peroxidase. However, … such that increased amounts of a neurotoxic form of amyloid β-…

Naturally Occurring Epilepsy and Status Epilepticus in Sea Lions

PS Buckmaster - Models of Seizures and Epilepsy, 2017 - Elsevier
… They are naturally exposed to domoic acid (DA), a glutamate … Sea lions could be a large
animal model to test novel … Neuron loss is most variable for granule cells whose numbers …

Cytomorphological Analysis and Interpretation of Nitric Oxide-Mediated Neurotoxicity in Sleep-Deprived Mice Model

R Chittora, A Jain, SD Shukla… - Annals of …, 2022 - journals.sagepub.com
… nNOS positive neurons are found in the cerebral cortex, the … (in granule cells) 17 and intensely
stained neurons have … , and depletion of catalase activity, and reduced glutathione levels …

Nervous system

DB Rao, ID Pardo, JH Chang, B Bolon… - … Handbook of Toxicologic …, 2024 - Elsevier
… of neurotoxicity, known mechanisms of neurotoxic injury, and … Impaired GABAergic
transmission, such as by domoic acid … targeted since the advent of genetic engineering and the …

Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo [a] pyrene-induced germ cell apoptosis

J Lim, U Luderer - Toxicology and applied pharmacology, 2018 - Elsevier
… Gclm−/− mice were generated by disrupting the Gclm gene by replacing exon 1 with a β-…
In our recent study using the same 13.5 dpc ovary culture model, 1000 ng/ml BaP caused a …

[PDF][PDF] The Effects of Lifelong Glutathione Deficiency on Functional Decline and Redox Signaling

JT Mock - 2018 - unthsc-ir.tdl.org
… -/- mice already have oxidative damage in cerebellar neurons at 4 months [76], and we …
An alternative model of chronic neuronal GSH depletion, is the excitatory amino acid carrier…