… Huntington's disease (HD) is a genetic, progressive and fatal … It appears that some features
of HD result from the depletion of … as micromoles of reduced glutathione per mg of protein. …

… can exert increased neurotoxicity with widespread astrogliosis [… In addition, BH4 non-hereditable
or genetic deficiencies … regulation of the rat glutathione S-transferase Ya subunit gene. …

… shows that pharmacologic or genetic inactivation of PPARγ … acute SE model and one using
a chronic epilepsy model and … Troxerutin counteracts domoic acid-induced memory deficits in …

… of protective genes and antioxidant enzymes such as the phase II detoxifying enzymes
glutathione S-… (MPTP) was used to produce neurotoxicity of neurons in the substantia nigra, and …

… neural-specific depletion of genes required for autophagy … may provide therapeutic value
and reduce neurotoxicity in a … superoxide dismutase (SOD) and glutathione peroxidase (GPx), …

… Genomic tools such as transcriptomics, proteomics and genetic … Domoic acid, a kainic acid
analogue, is a naturally occurring … role in the synthesis of glutathione; a potent antioxidant. …

… HD is the most frequent hereditary cause of chorea and is also … pathways responsible for
neurotoxicity.” Journal of Biological … Some poisons, such as domoic acid (an amnesic shellfish …

… Furthermore, the neurotoxicity of BDE-47 leads to a … , we observed the levels of ROS and
glutathione (GSH) and the … and regulatory subunits in the brain of domoic acid-treated mice [42]. …

… The neurotoxicity of rotenone was also alleviated by several … In a recent work, cells deficient
in Drp1 presented elongated … the expression of nuclear genes required for mitochondrial …

… toxins from marine dinoflagellates; and domoic acid (DA) from a … to produce the neurotoxic
amino acid BMAA, including … glutathione peroxidase activities, accompanied by short-term …