Stem cells as a promising tool for the restoration of brain neurovascular unit and angiogenic orientation
… after ischemia through upregulating VEGF expression [47]. Following brain injury, astrocytic
control of the neurovascular unit becomes incompetent due to an induction of VEGF and a …
control of the neurovascular unit becomes incompetent due to an induction of VEGF and a …
[HTML][HTML] Pericytes and the Neurovascular Unit: The Critical Nexus of Alzheimer Disease Pathogenesis?
SP Cercy - Exploratory Research and Hypothesis in Medicine, 2021 - xiahepublishing.com
… of Aβ monomers to form toxic oligomeric species but APOE4 … thrombin, fibrinogen, and
fibrin—which thrombin cleaves from … contribute to the induction of oxidative stress by glial cells. …
fibrin—which thrombin cleaves from … contribute to the induction of oxidative stress by glial cells. …
[HTML][HTML] Oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging
M Mladenov, L Lubomirov, O Grisk, D Avtanski… - Antioxidants, 2023 - mdpi.com
… effect of ROS accumulation on the neurovascular unit is … growth factor (VEGF), thus having
pleiotropic effects on a variety of … at high doses of up to 12 g/day [155], while toxicity studies in …
pleiotropic effects on a variety of … at high doses of up to 12 g/day [155], while toxicity studies in …
Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches
… endothelial growth factor (VEGF) and Notch homolog protein … mitochondrial dysfunction and
increased oxidative stress [36]. … RhoA by thrombin in endothelial hyperpermeability: Role of …
increased oxidative stress [36]. … RhoA by thrombin in endothelial hyperpermeability: Role of …
Upregulation of thrombin/matrix metalloproteinase-1/protease-activated receptor-1 chain in proliferative diabetic retinopathy
… MMP-1 and thrombin levels with the levels of the angiogenic factor VEGF. In addition, to …
anesthetized by intraperitoneal injection of an overdose of chloral hydrate and sacrificed by …
anesthetized by intraperitoneal injection of an overdose of chloral hydrate and sacrificed by …
Pericytes of the neurovascular unit: key functions and signaling pathways
MD Sweeney, S Ayyadurai, BV Zlokovic - Nature neuroscience, 2016 - nature.com
… (for example, fibrinogen, thrombin, plasminogen, erythrocyte-derived … This model offers not
only an explanation for the dose … Treatment with an anti-VEGF antibody was least effective in …
only an explanation for the dose … Treatment with an anti-VEGF antibody was least effective in …
Vascular cognitive impairment: pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments
VA Parfenov, OD Ostroumova… - Neuropsychiatric …, 2019 - Taylor & Francis
… contributing to CBVD, neurovascular unit alterations, and … , C, and E, which can facilitate
oxidative stress, tend to decrease in … Under physiological conditions, low concentration of VEGF, …
oxidative stress, tend to decrease in … Under physiological conditions, low concentration of VEGF, …
[HTML][HTML] Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease
… structural component of the neurovascular unit that constitutes the … Erythrocytes can contribute
to thrombin generation … [33,34] and oxidative stress causes endothelial activation leading …
to thrombin generation … [33,34] and oxidative stress causes endothelial activation leading …
Intracerebral hemorrhage, oxidative stress, and antioxidant therapy
X Duan, Z Wen, H Shen, M Shen… - Oxidative medicine and …, 2016 - Wiley Online Library
… the components of the neurovascular unit, constituting gray and … of thrombin during blood
coagulation, the toxic effects of … dose of 10–50 mg/kg depending on species, and this beneficial …
coagulation, the toxic effects of … dose of 10–50 mg/kg depending on species, and this beneficial …