Inhibition of toll-like receptor-4 (TLR-4) improves neurobehavioral outcomes after acute ischemic stroke in diabetic rats: possible role of vascular endothelial TLR-4

Y Abdul, M Abdelsaid, W Li, RC Webb… - Molecular …, 2019 - Springer
… Iron can induce oxidative stress, but its role in endothelial … phenotype; (3) VEGF mediates
an angiogenic response in … necessary for survival within the neurovascular unit [31]. Thus, …

The complex and integral roles of pericytes within the neurovascular unit in health and disease

BA Sutherland - Biology of pericytes–Recent advances, 2021 - Springer
… Paracrine signaling between cells of the neurovascular unit. … modulate endothelial cell function
including VEGF-A, Angiopoietin-1… -induced oligodendrocyte toxicity as well as roles in the …

Neuron‐generated thrombin induces a protective astrocyte response via protease activated receptors

PS Rajput, J Lamb, S Kothari, B Pereira, D Soetkamp… - Glia, 2020 - Wiley Online Library
… toward a protective versus toxic phenotype are not fully known … thrombin when signaling glial
cells in the neurovascular unit. … the effect of various OGD times and several thrombin doses

[HTML][HTML] Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption

Y Wang, J Wu, J Wang, L He, H Lai, T Zhang, X Wang… - Mitochondrion, 2023 - Elsevier
… , abnormal angiogenesis, neurovascular decoupling, and the … to the accumulation of toxic
substances around blood vessels … Mitochondria can regulate angiogenesis through the VEGF/…

[HTML][HTML] Vascular effects on cerebrovascular permeability and neurodegeneration

N Sulimai, J Brown, D Lominadze - Biomolecules, 2023 - mdpi.com
… actions on components of the neurovascular unit (NVU) that may affect … of abnormal proteins,
oxidative stress, early synaptic … Hb-induced toxicity [100], the prevailing role of haptoglobin …

The role of hypoxia-inducible factor 1 in mild cognitive impairment

O Iyalomhe, S Swierczek, N Enwerem, Y Chen… - Cellular and molecular …, 2017 - Springer
… counter oxidative stress. HIF-1 also improves cerebral blood flow which opposes the toxicity
… HIF-1 target genes (erythropoietin and VEGF) were associated with improved vasoreactivity …

[HTML][HTML] The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

K Yang, L Zeng, X Yuan, S Wang, A Ge, H Xu… - Biomedicine & …, 2022 - Elsevier
… each neurovascular unit during post-stroke hypoxia and reperfusion play an important role
… the pathological process of ferroptosis in the neurovascular unit of acute stroke. Some drugs …

Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications

DR Yang, MY Wang, CL Zhang, Y Wang - Frontiers in Endocrinology, 2024 - frontiersin.org
… This effect can be alleviated by VEGF-B deficiency targeting … EndMT can also be induced
by oxidative stress. The … In human aortic endothelial cells, high glucose and thrombin reduce …

[HTML][HTML] The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

YL Zhang, J Wang, ZN Zhang, Q Su… - Neural Regeneration …, 2022 - journals.lww.com
… cerebrovascular effects by promoting oxidative stress, … changes in the neurovascular units
constituting the BBB contribute … VEGF-stimulated endothelial nitric oxide synthase and VEGF-…

Patching up the permeability: the role of stem cells in lessening neurovascular damage in amyotrophic lateral sclerosis

M Monsour, S Garbuzova-Davis… - Stem Cells …, 2022 - academic.oup.com
… This review elucidates the role of the neurovascular unit in … hypoxia response element in
the VEGF gene promotor blocks … These patients also had increased IgG, fibrin, and thrombin in …