Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
neutrophil-derived antimicrobial molecules 45 . NETs entrap and possibly kill bacteria 45
but also play major roles in various inflammatory … could serve as targets for dampening NET-…

[HTML][HTML] Neutrophils as a therapeutic target in cancer

Z Granot - Frontiers in immunology, 2019 - frontiersin.org
… in cancer and potential therapeutic targets. Neutrophils play … from the ECM by neutrophil
derived MMP9. Neutrophil mediate … resolution of tumor associated inflammation. However, since …

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

D Geh, J Leslie, R Rumney, HL Reeves… - Nature reviews …, 2022 - nature.com
… into the circulation and migration into inflamed and non-inflamed tissues 55 has revealed that
Neutrophil-derived ROS also promote epithelial cell senescence, which can underpin the …

[HTML][HTML] Neutrophils as a potential therapeutic target in Alzheimer's disease

ML Aries, T Hensley-McBain - Frontiers in Immunology, 2023 - frontiersin.org
Neutrophil-derived inflammation and regulation are a potential potent novel therapeutic target
for AD progression. Future studies should further investigate neutrophil functionality in AD. …

Neutrophils as an emerging therapeutic target and tool for cancer therapy

MA Subhan, VP Torchilin - Life Sciences, 2021 - Elsevier
… , and subsequent production of neutrophil-derived MMP9 prompted angiogenesis, growth of
… Nanovesicles prepared from neutrophil membrane can target inflamed tissues and enhance …

Neutrophils: Novel key players in Rheumatoid Arthritis. Current and future therapeutic targets

I Cecchi, IA de la Rosa, E Menegatti, D Roccatello… - Autoimmunity …, 2018 - Elsevier
… biological agents, on their inflammatory profile and functions. Then we show a number of
neutrophil-derived molecules that might serve as novel, potential targets for therapeutic agents. …

Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications

D Muthas, A Reznichenko, CA Balendran… - Scandinavian journal …, 2017 - Taylor & Francis
… CRP will not be further covered in this review since it is not a neutrophil-derived protein. Both
… CD16 an especially attractive potential therapeutic target in inflammatory diseases, as its …

[HTML][HTML] Tumor-associated neutrophils and neutrophil-targeted cancer therapies

H Que, Q Fu, T Lan, X Tian, X Wei - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
… infections and are involved in a range of inflammatory disorders in the body. In recent years,
… More recently, neutrophils have been proposed as a potential target in cancer therapy for …

Biological roles of neutrophil-derived granule proteins and cytokines

MA Cassatella, NK Östberg, N Tamassia… - Trends in …, 2019 - cell.com
… granule proteins and cytokines can synergize to modulate inflammation and tumor development…
inflammation, or for delivering modified neutrophil-borne proteins to boost host defense. …

[HTML][HTML] Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases

Y Su, J Gao, P Kaur, Z Wang - Pharmaceutics, 2020 - mdpi.com
… roles as potential therapeutic targets in inflammatory diseases… targets neutrophils or
macrophages for treating inflammation-… For example, neutrophil derived NETs contain plenty of …