Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino - Nature reviews Drug discovery, 2016 - nature.com
… liver disease converge to common, stereotyped patterns of injury, inflammation and fibrogenesis
in NASH. Molecular mechanisms … are therefore potential therapeutic targets, including …
in NASH. Molecular mechanisms … are therefore potential therapeutic targets, including …
Immunological mechanisms and therapeutic targets of fatty liver diseases
… mechanisms differ to some extent. Here, we review the roles of multiple … mechanisms
and therapeutic targets related to the inflammation associated with fatty liver diseases and the …
and therapeutic targets related to the inflammation associated with fatty liver diseases and the …
Emerging molecular targets for treatment of nonalcoholic fatty liver disease
Z Chen, Y Yu, J Cai, H Li - Trends in Endocrinology & Metabolism, 2019 - cell.com
… Several therapeutic targets regulating the lipid metabolism … as the most common chronic liver
disease worldwide. Disequilibrium … This review summarizes the emerging molecular targets …
disease worldwide. Disequilibrium … This review summarizes the emerging molecular targets …
The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: Molecular mechanism and promising therapeutic targets
S Yu, Z Wang, L Ding, L Yang - Life sciences, 2020 - Elsevier
… process of NAFLD, and the specific regulatory mechanism of TFEB activity. We further
recapitulate TFEB as a promising therapeutic target for NAFLD, primarily through the regulation of …
recapitulate TFEB as a promising therapeutic target for NAFLD, primarily through the regulation of …
New therapeutic targets in alcoholic hepatitis
D Arsene, O Farooq, R Bataller - Hepatology international, 2016 - Springer
… (AH) is an acute-on-chronic condition, diagnosed clinically by new-onset jaundice and/or
ascites in the setting of ongoing alcohol abuse and underlying alcoholic liver disease (ALD). …
ascites in the setting of ongoing alcohol abuse and underlying alcoholic liver disease (ALD). …
Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects
R Teschke - Biomedicines, 2018 - mdpi.com
… to identify publications for the following terms: Alcoholic liver disease, alcoholic fatty liver
disease, alcoholic steatohepatitis, alcoholic hepatitis, alcoholic cirrhosis, alcohol metabolism, …
disease, alcoholic steatohepatitis, alcoholic hepatitis, alcoholic cirrhosis, alcohol metabolism, …
[HTML][HTML] Alcoholic liver disease: A current molecular and clinical perspective
K Ohashi, M Pimienta, E Seki - Liver research, 2018 - Elsevier
… molecular mechanisms and those currently emerging, such as EVs and the crosstalk between
liver and adipose tissues, and reviewed potential targets, such … , for effective therapies. To …
liver and adipose tissues, and reviewed potential targets, such … , for effective therapies. To …
Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment
Y Yang, Y Zhao, W Li, Y Wu, X Wang, Y Wang… - European Journal of …, 2020 - Elsevier
… In this review, we summarized the main pathways and pathogenic mechanisms of NAFLD,
as well as introduced the main potential therapeutic targets and the corresponding …
as well as introduced the main potential therapeutic targets and the corresponding …
Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease
… Emerging data from these studies with drugs targeting diverse molecular mechanisms show
… as a possible therapeutic target for combating metabolic diseases, including NAFLD [64]. …
… as a possible therapeutic target for combating metabolic diseases, including NAFLD [64]. …
[HTML][HTML] Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases
YS Kim, SG Kim - Clinical and Molecular Hepatology, 2020 - ncbi.nlm.nih.gov
… liver diseases. Thus, autophagy-related molecules can be potential therapeutic targets for
liver … In this review, we attempted to summarize the molecular mechanisms underlying ALD …
liver … In this review, we attempted to summarize the molecular mechanisms underlying ALD …