[HTML][HTML] New antimicrobial peptide-antibiotic combination strategy for Pseudomonas aeruginosa inactivation
W Han, Z Wei, TA Camesano - Biointerphases, 2022 - pubs.aip.org
Novel antimicrobials or new treatment strategies are urgently needed to treat Pseudomonas
aeruginosa (P. aeruginosa) related infections and especially to address the problem of
antibiotic resistance. We propose a novel strategy that combines the human antimicrobial
peptide (AMP) LL37 with different antibiotics to find synergistic AMP-antibiotic combinations
against P. aeruginosa strains in vitro. Our results showed that LL37 exhibited synergistic
inhibitory and bactericidal effects against P. aeruginosa strains PAO1 and PA103 when …
aeruginosa (P. aeruginosa) related infections and especially to address the problem of
antibiotic resistance. We propose a novel strategy that combines the human antimicrobial
peptide (AMP) LL37 with different antibiotics to find synergistic AMP-antibiotic combinations
against P. aeruginosa strains in vitro. Our results showed that LL37 exhibited synergistic
inhibitory and bactericidal effects against P. aeruginosa strains PAO1 and PA103 when …
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