[HTML][HTML] New cytotoxic indole-type alkaloids obtained from Rhazya stricta leaves
ZH Abdul-Hameed, WM Alarif, TR Sobhi… - South African journal of …, 2021 - Elsevier
South African journal of botany, 2021•Elsevier
Seven alkaloids of indole nucleus were isolated from Rhazya stricta (Apocynaceae). Two of
which are new epi-rhazyaminine (1) and 20-epi-sitsirikine (2), while the rest are known;
eburenine (3), strictamine (4),(16 R)-E-isositsirikine (5), antirhine (6), and strictanol (7). The
chemical structures of the isolated compounds were elucidated by interpretation of the
obtained spectral data 1D (1 H, 13 C and DEPT) and 2D (COSY, HSQC, HMBC and
NOESY) NMR, UV, IR and MS. Compounds 1-7 were tested against three cancer cell lines; …
which are new epi-rhazyaminine (1) and 20-epi-sitsirikine (2), while the rest are known;
eburenine (3), strictamine (4),(16 R)-E-isositsirikine (5), antirhine (6), and strictanol (7). The
chemical structures of the isolated compounds were elucidated by interpretation of the
obtained spectral data 1D (1 H, 13 C and DEPT) and 2D (COSY, HSQC, HMBC and
NOESY) NMR, UV, IR and MS. Compounds 1-7 were tested against three cancer cell lines; …
Abstract
Seven alkaloids of indole nucleus were isolated from Rhazya stricta (Apocynaceae). Two of which are new epi-rhazyaminine (1) and 20-epi-sitsirikine (2), while the rest are known; eburenine (3), strictamine (4), (16 R)-E-isositsirikine (5), antirhine (6), and strictanol (7). The chemical structures of the isolated compounds were elucidated by interpretation of the obtained spectral data 1D (1H, 13C and DEPT) and 2D (COSY, HSQC, HMBC and NOESY) NMR, UV, IR and MS. Compounds 1-7 were tested against three cancer cell lines; human colorectal carcinoma (HCT-116), prostate cancer (PC-3), human hepatocellular liver carcinoma (HepG2) and normal adult African green monkey kidney (VERO).
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