Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches
A Vlasie, SC Trifu, C Lupuleac… - Experimental and …, 2022 - spandidos-publications.com
… treatment/management of restless legs syndrome (RLS) a sensorimotor neurological disorder…
compulsion to move the legs and a sense of restlessness at rest most commonly occurring …
compulsion to move the legs and a sense of restlessness at rest most commonly occurring …
Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: implications on the dopaminergic system and PTPRD
MA Morais, B Franco, ASS Holanda… - Sleep Medicine, 2023 - Elsevier
… Dopaminergic dysfunction, iron reduction and variations in the PTPRD gene (protein
tyrosine phosphatase receptor type delta) may be associated with restless leg syndrome (RLS). …
tyrosine phosphatase receptor type delta) may be associated with restless leg syndrome (RLS). …
Consensus guidelines on the construct validity of rodent models of restless legs syndrome
…, International Restless Legs Syndrome … - Disease models & …, 2022 - journals.biologists.com
… Our understanding of the causes and natural course of restless legs syndrome (RLS) is …
In this article, we establish new guidelines for the construct validity of RLS rodent models. …
In this article, we establish new guidelines for the construct validity of RLS rodent models. …
Iron and restless legs syndrome: treatment, genetics and pathophysiology
… In this article, we review the original findings from MRI and autopsy studies that demonstrated
brain iron status is insufficient in individuals with restless legs syndrome (RLS). The …
brain iron status is insufficient in individuals with restless legs syndrome (RLS). The …
Restless legs syndrome
S Clemens - Neurobiology of Brain Disorders, 2023 - Elsevier
… of the symptoms and careful ongoing titration of pharmacological treatment options are
needed to manage the symptoms and their responsiveness to individual drug paradigms. …
needed to manage the symptoms and their responsiveness to individual drug paradigms. …
Noninvasive vagus nerve stimulation: a new therapeutic approach for pharmacoresistant restless legs syndrome
S Hartley, G Bao, M Zagdoun, S Chevallier… - … : Technology at the …, 2023 - Elsevier
… nerve stimulation on severe restless legs syndrome (RLS) resistant to pharmacotherapy. …
quality of life as measured with the Restless Legs Syndrome Quality of Life scale (RLSQOL), 19 …
quality of life as measured with the Restless Legs Syndrome Quality of Life scale (RLSQOL), 19 …
[HTML][HTML] Putative animal models of restless legs syndrome: A systematic review and evaluation of their face and construct validity
… Restless legs syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is
characterized by an urge to move the legs, which is often accompanied by periodic limb …
characterized by an urge to move the legs, which is often accompanied by periodic limb …
Iron replacement therapy in restless legs syndrome
C Garcia-Malo, C Miranda, S Romero Peralta… - Current Treatment …, 2020 - Springer
Purpose of review The main purpose of this manuscript is to review the existing clinical
evidence about when iron replacement therapy should be initiated for RLS/WED, and how it …
evidence about when iron replacement therapy should be initiated for RLS/WED, and how it …
Targeting the adenosinergic system in restless legs syndrome: A pilot,“proof-of-concept” placebo-controlled TMS-based protocol
G Lanza, M Salemi, MP Mogavero, V Catania… - Plos one, 2024 - journals.plos.org
… Restless Legs Syndrome (RLS) is a common sleep disorder characterized by an urge to
move the legs that is responsive to movement (particularly during rest), periodic …
move the legs that is responsive to movement (particularly during rest), periodic …
Contribution of transcranial magnetic stimulation in restless legs syndrome: pathophysiological insights and therapeutical approaches
… pathophysiologic and neurochemical aspects of restless legs syndrome (RLS). … paradigms
to obtain a measure of various aspects of cortical excitability. The different TMS paradigms …
to obtain a measure of various aspects of cortical excitability. The different TMS paradigms …