Imaging immunity in lymph nodes: Past, present and future

J Butler, A Sawtell, S Jarrett, J Cosgrove, R Leigh… - Biophysics of …, 2016 - Springer
models) have provided immunologists with specialized tools to quantify the molecular and
cellular mechanisms driving immune function in … a LN tissue explant model where substances …

[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

Y Shou, SC Johnson, YJ Quek, X Li, A Tay - Materials Today Bio, 2022 - Elsevier
lymph node in immunity protection followed by recent advances using biomaterials to create
in vitro/vivo LN-mimicking models to recreate the lymphoid tissueimmunological function [48…

Lymph node–an organ for T‐cell activation and pathogen defense

G Gasteiger, M Ataide… - Immunological reviews, 2016 - Wiley Online Library
… Additionally, besides barrier tissues, the lymph node is a critical … Here, we explain how the
lymph node is structurally and … a fully functional CD8 T-cell memory response in various model

Development and immunological function of lymph node stromal cells

NB Pikor, HW Cheng, L Onder… - … Journal of Immunology, 2021 - journals.aai.org
… In this review, we go over recent advances in genetic models … lymphoid tissue organizer
(LTo) cells and lymphoid tissue … As with any new technology, it is important to understand the …

Lymph node stromal cells: cartographers of the immune system

AT Krishnamurty, SJ Turley - Nature immunology, 2020 - nature.com
… facilitate immune cell entry from surrounding tissues. Pioneering … new genetic or pharmacologic
tools for parsing the functions … two-cell model in which LTi and mLTo cells interact to form …

A human immune system mouse model with robust lymph node development

Y Li, G Masse-Ranson, Z Garcia, T Bruel, A Kök… - Nature …, 2018 - nature.com
… Human immune system (HIS) mice are powerful tools for … human T FH cell differentiation in
lymphoid tissues of BRGST HIS … means to dissect the immunological features of HIV latency …

The pig as a model for immunology research

R Pabst - Cell and tissue research, 2020 - Springer
… In the pig, the medullary tissue is in the periphery of the lymph node and the cortical part
in the central area. Thus, T and B cells are mainly found in an atypical localization. Each …

Lymph nodes-on-chip: Promising immune platforms for pharmacological and toxicological applications

A Shanti, N Hallfors, GA Petroianu… - Frontiers in …, 2021 - frontiersin.org
tissue culture plates. In addition they represent improved and attractive platforms for various
applications in immunology, … here focuses on models that mimic the lymph node physiology, …

Advanced model systems and tools for basic and translational human immunology

LE Wagar, RM DiFazio, MM Davis - Genome medicine, 2018 - Springer
… Human PBMCs have also been used to successfully reflect some aspects of tissue-resident
and lymph node biology in response to vaccine antigens. Using a system called human …

Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski - Nature Reviews Genetics, 2019 - nature.com
cells are at the core of immunological tumour control and response to anticancer therapies
5,7,8 . After priming and activation by dendritic cells in draining lymph nodes … optimal models