Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen specific

LH Tostanoski, YC Chiu, JM Gammon, T Simon… - Cell reports, 2016 - cell.com
… In a mouse MS model, intra-LN introduction of encapsulated … we used direct lymph node
(LN) delivery as a tool to isolate … MPs, to probe the local tissue- and cell-level changes in LNs …

[HTML][HTML] Towards the development of human immune-system-on-a-chip platforms

A Polini, LL Del Mercato, A Barra, YS Zhang… - Drug Discovery …, 2019 - Elsevier
… decades provided convenient models for immunologists, and have … the lymph draining from
peripheral tissues and carrying tissue-… Lymph node structure and an example of an ex vivo …

Tertiary lymphoid structures in cancer–considerations for patient prognosis

L Munoz-Erazo, JL Rhodes, VC Marion… - … & molecular immunology, 2020 - nature.com
… such as lymph nodes and can contain B-cell follicles and … Model of the composition of a
tertiary lymphoid structure. … TLS in broad regions in peritumoral tissue up to 7 mm from the …

The internal conduit system of the swine inverted lymph node

L Dubreil, M Ledevin, C Hervet, D Menard… - … in immunology, 2022 - frontiersin.org
… Using up to date microscopy tools, we described the … cell-associated antigens are drained
from peripheral tissues to … We thus propose here a refined model of the lymphatic and blood …

Ectopic lymphoid follicles: inducible centres for generating antigen‐specific immune responses within tissues

GW Jones, SA Jones - Immunology, 2016 - Wiley Online Library
Lymph nodes are strategically located throughout the body … cells as they are trafficking from
peripheral organs and tissue. … models of melanoma and lung carcinoma, the development of …

Modulation of immunity by lymphatic dysfunction in lymphedema

Y Yuan, V Arcucci, SM Levy, MG Achen - Frontiers in immunology, 2019 - frontiersin.org
… (20), lymph node transplantation (21) and other regional tissue … + T cells were activated in
skin-draining lymph nodes and … prevented lymphedema in the mouse tail model employed in …

Lymph node conduits transport virions for rapid T cell activation

GV Reynoso, AS Weisberg, JP Shannon… - … immunology, 2019 - nature.com
… Current models fail to explain how virus-infected cells rapidly … minutes of deposition into
peripheral tissues 10 . Virions present … Thus, viruses serve as the perfect tool to uncover a …

Detection of PD-L1–Expressing Myeloid Cell Clusters in the Hyaluronan-Enriched Stroma in Tumor Tissue and Tumor-Draining Lymph Nodes

PR Dominguez-Gutierrez, EP Kwenda… - … of Immunology, 2022 - journals.aai.org
lymph nodes (TDLNs), but not in distant lymph nodes (LNs). Our results support the idea
that HA produced by stroma and tumor cells … In addition to the bladder tumor model, we also …

Tissues, not blood, are where immune cells function

DL Farber - Nature, 2021 - nature.com
tissue (see ‘Human tissues for immunology’). In surgeries from tonsillectomies to tumour
removals, lymph nodes … gut tissues that are rich in immune cells and lymph nodes associated …

A short field guide to fibroblast function in immunity

MB Buechler, SJ Turley - Seminars in immunology, 2018 - Elsevier
lymph nodes (LN), spleen and Peyer’s Patches, are tissues … This model aims to highlight
the tripartite manner in which … to a dearth of genetic tools so we endeavored to acknowledge …