The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism
S Zhang, C Xie - Life sciences, 2017 - Elsevier
… 3-Oxoacid CoA-transferase 1 (OXCT1), also named succinyl-CoA:3-ketoacid CoA transferase
(… Ketone body oxidation is required for postnatal survival in mice and for adaptation to low …
(… Ketone body oxidation is required for postnatal survival in mice and for adaptation to low …
[HTML][HTML] Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer
CY Hwang, W Choe, KS Yoon, J Ha, SS Kim, EJ Yeo… - Nutrients, 2022 - mdpi.com
… -CoA synthase 2 and succinyl-CoA:3-oxoacid-CoA transferase, respectively. KBs … nitration
in the hearts of streptozotocin-treated (diabetic) or endotoxin-exposed (inflammatory) rats…
in the hearts of streptozotocin-treated (diabetic) or endotoxin-exposed (inflammatory) rats…
[HTML][HTML] Cardiac ketone body metabolism
AA Kadir, K Clarke, RD Evans - … et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
… 1 (OXCT1), also called succinyl-CoA:3-oxoacid-CoA transferase (… tyrosine nitration in
diabetes [15,16] or following endotoxin … , whilst nitration of SCOT tryptophan residues in aged rat …
diabetes [15,16] or following endotoxin … , whilst nitration of SCOT tryptophan residues in aged rat …
Anticatabolic effects of ketone bodies in skeletal muscle
… insult provided by lipopolysaccharide (LPS) endotoxin. This is salient because with aging, …
endotoxemia results in nitration and inactivation of succinyl-CoA:3-oxoacid CoA transferase …
endotoxemia results in nitration and inactivation of succinyl-CoA:3-oxoacid CoA transferase …
Protein nitration is a physiological regulator of cardiac lactate dehydrogenase active site loop mobility and activity
C Nogales, J Frijhoff, D Thoenges, RB Sessions… - bioRxiv, 2018 - biorxiv.org
… rat and pig, we identify it as lactate dehydrogenase (LDH). Mechanistically, LDH’s degree of
basal nitration … (29) reported Trp nitration of succinyl-CoA:3-ketoacid CoA transferase (SCOT…
basal nitration … (29) reported Trp nitration of succinyl-CoA:3-ketoacid CoA transferase (SCOT…
iNOS as a metabolic enzyme under stress conditions
S Anavi, O Tirosh - Free Radical Biology and Medicine, 2020 - Elsevier
… IR inducers, such as endotoxins, pro-inflammatory cytokines, … HFD-fed wt mice but not in
iNOS −/− mice under the same diet. … Following the nitration of the ortho position of tyrosine, the …
iNOS −/− mice under the same diet. … Following the nitration of the ortho position of tyrosine, the …
[HTML][HTML] Regulation of ketone body metabolism and the role of PPARα
M Grabacka, M Pierzchalska, M Dean… - International journal of …, 2016 - mdpi.com
… by a succinyl-CoA-dependent transferase (succinyl-CoA:3-ketoacid-CoA transferase, SCOT)…
effects seen in the kidneys of mice following infusion of bHB via osmotic pump [67]. The full …
effects seen in the kidneys of mice following infusion of bHB via osmotic pump [67]. The full …
[HTML][HTML] Unveiling the human nitroproteome: Protein tyrosine nitration in cell signaling and cancer
I Griswold-Prenner, AK Kashyap, S Mazhar… - Journal of Biological …, 2023 - ASBMB
… We have also analyzed this new resource to provide insight into the role of tyrosine nitration
… tyrosine nitration are also sites of phosphorylation suggesting an extensive role for nitration …
… tyrosine nitration are also sites of phosphorylation suggesting an extensive role for nitration …
[HTML][HTML] AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation
L Zhang, Y Lu, J An, Y Wu, Z Liu, MH Zou - Scientific Reports, 2024 - nature.com
… of ketolysis: succinyl-CoA:3-ketoacid CoA transferase (SCOT), … AMPKα1 ΔMusc mice were
lower than in WT mice after two … in SCOT tyrosine nitration between AMPKα2 activation and …
lower than in WT mice after two … in SCOT tyrosine nitration between AMPKα2 activation and …
Effect of systemic administration of lipopolysaccharides derived from Porphyromonas gingivalis on gene expression in mice kidney
… ), 3-oxoacid CoA transferase 2A (Oxct2a), and chemokine (C motif) receptor 1(Xcr1) are known.
Table 5 Upregulated genes following microarray analysis of mice … to the CoA transferase …
Table 5 Upregulated genes following microarray analysis of mice … to the CoA transferase …