… of lipid-derived electrophilic species, discuss other Michael acceptor-containing drugs
engaged in clinical trials or already approved, and show the emerging therapeutic potential of this …

… There are reports focusing on the knowledge of NO 2 -FAon the therapeutic potential of
kidney inflammatory diseases and metabolic disorders, with special emphasis on acute kidney …

… potentially reduce the risk of metabolic diseases. To identify the specific mechanism of action
and therapeutic potential … for the development of new therapeutics for metabolic diseases. …

… than as substrates for signaling mediator biosynthesis. At about the same time, seminal
discoveries that led to the fields of free radical biology and redox signaling were being made. …

… This illustrates the therapeutic potential for dual HSF1-NRF2 activators including NO 2 -FA,
given that the pathogenesis of many diseases involves both increased oxidative stress and …

… therapeutic potential against many diseases. In general, NO 2 -FAs inhibit nuclear factorκ-B
(NF-κB), and simultaneously they activate nuclear factor (erythroid derived)-like 2 (Nrf2), …

… Ongoing Phase II clinical trials will determine the therapeutic potential of CXA-10 in areas of
… 2 -FA can give rise to the formation of an array of secondary species with potentially different …

… where in macrophages, key regulatory proteins in TLR, JAK-STAT, NF-κB, nuclear hormone
receptor and redox signaling pathways that are central to macrophage function are targeted. …

… The nitro-fatty acid detection in other plant species highlight a ubiquitous distribution of
nitro-fatty acids in plant kingdom and the potential signaling actions of these molecules in plant …

… 2 ) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty
acids (NO 2 -FA) with unique biochemical and signaling properties. During the last decade, NO …