Functional long non-coding RNAs evolve from junk transcripts

AF Palazzo, EV Koonin - Cell, 2020 - cell.com
… ), its opponents do not deny the existence of functional lncRNAs. Instead, they maintain that
eukaryotic genomes produce a vast amount of junk RNA (we realize that the use of this term …

[HTML][HTML] Non-coding RNA: it's not junk

CR Boland - Digestive diseases and sciences, 2017 - ncbi.nlm.nih.gov
RNA—if at low level.[5] Our genome also encodes tens of thousands of long non-coding RNAs
… -encoding messenger RNAs (mRNAs), but appear to be functionally different than shorter …

Non-coding RNA: it's not junk

C Richard Boland - Digestive Diseases and Sciences, 2017 - Springer
RNA—if at low level [5]. Our genome also encodes tens of thousands of long non-coding RNAs
… encoding messenger RNAs (mRNAs), but appear to be functionally different than shorter …

… RNAs junk or treasure? An attempt to explain and reconcile opposing viewpoints of whether the human genome is mostly transcribed into non‐functional or functional …

NG Walter - BioEssays, 2024 - Wiley Online Library
… or non-coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic
DNA is “junk”… New insights into long non-coding RNA MALAT1 in cancer and metastasis. …

LncRNAs in cancer: from garbage to junk

M Aprile, V Katopodi, E Leucci, V Costa - Cancers, 2020 - mdpi.com
… (XIST) RNA was one of the first long non-coding RNAs to be … is ANRIL (antisense non-coding
RNA in the INK4 locus). … and p15 INK4B by non-coding RNAs residing in this genomic …

From junk to function: LncRNAs in CNS health and disease

R Policarpo, A Sierksma, B De Strooper… - Frontiers in molecular …, 2021 - frontiersin.org
… sequencing technologies helped to uncover the existence of tens of thousands of long
non-coding RNAs (lncRNAs) that arise from the dark matter of the genome. These lncRNAs were …

[PDF][PDF] Are non‐protein coding RNAs junk or treasure?

NG Walter - 2024 - sites.lsa.umich.edu
… or non-coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic
DNA is “junk”… New insights into long non-coding RNA MALAT1 in cancer and metastasis. …

When junk DNA turns functional: transposon-derived non-coding RNAs in plants

FD Ariel, PA Manavella - Journal of experimental botany, 2021 - academic.oup.com
… , sequestering active small RNAs, and forming duplexes with DNA or other RNA molecules.
In … the functional and mechanistic paradigms of TE-derived long and small non-coding RNAs

Long Non-coding RNA (s): Is the Junk Worth It?

A Mishra - Integrative Approaches to Biotechnology, 2024 - taylorfrancis.com
Functional activity of long non-coding RNAs is not limited to the physiological events in
cellular processes, it has a very important and regulatory role in several signaling pathways …

Decoding the Non-coding: Tools and Databases Unveiling the Hidden World of “JunkRNAs for Innovative Therapeutic Exploration

U Chaudhary, S Banerjee - ACS Pharmacology & Translational …, 2024 - ACS Publications
Non-coding RNAs are pivotal regulators of gene and protein … to understand the crosstalk
of non-coding RNAs, knowledge of … biological insights from seemingly “junk” data, these tools …