[HTML][HTML] Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger–containing 1 (UHRF1) for anti-cancer drug development
… of the status and stage of breast cancer; and may serve as a … novel diagnostic and prognostic
biomarker for gastric cancer [… The E3 ubiquitin ligase activity of the RING domain has been …
biomarker for gastric cancer [… The E3 ubiquitin ligase activity of the RING domain has been …
[HTML][HTML] Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors
Y Pan, Y Yang, R Huang, H Yang, Q Huang, Y Ji… - Breast Cancer …, 2022 - Springer
… This study explores the relationship between the E3 ubiquitin ligase Ring finger protein
126 (RNF126) and early breast cancer metastasis and tests the hypothesis that RNF126 …
126 (RNF126) and early breast cancer metastasis and tests the hypothesis that RNF126 …
[HTML][HTML] The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer
… Breast cancer patients consistent with its cancer-promoting effect [39]. These findings support
an oncogenic role for DTX1 in cancer… on the identification of novel DTX-regulated proteins, …
an oncogenic role for DTX1 in cancer… on the identification of novel DTX-regulated proteins, …
E3 ubiquitin ligase RNF180 reduces sensitivity of triple-negative breast cancer cells to Gefitinib by downregulating RAD51
P Liu, W Zhou, L Yang, C Zhang - Chemico-Biological Interactions, 2022 - Elsevier
… signify as a biomarker for metastatic breast cancer [11]. Moreover, … its ubiquitination, thus
overcoming the resistance of cancer … on the role of E3 ubiquitin ligase, RNF180 in regulating the …
overcoming the resistance of cancer … on the role of E3 ubiquitin ligase, RNF180 in regulating the …
[HTML][HTML] TRIM8 inhibits breast cancer proliferation by regulating estrogen signaling
Z Tian, J Tang, X Liao, Y Gong, Q Yang… - … Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
… Breast cancer (BC) is the most common female malignancy … that the E3 ubiquitin ligase
tripartite motif 8 (TRIM8) acts as a novel … via its RING domain in the cytoplasm and increases poly-…
tripartite motif 8 (TRIM8) acts as a novel … via its RING domain in the cytoplasm and increases poly-…
[HTML][HTML] E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability
H Xu, L Ju, Y Xiong, M Yu, F Zhou, K Qian… - Cell Death & …, 2021 - nature.com
… several cancers, including breast cancer 15 , prostate cancer 13 , gastric … novel therapeutic
targets for human cancers. In the current study, we focused on the role of E3 ubiquitin ligases …
targets for human cancers. In the current study, we focused on the role of E3 ubiquitin ligases …
[HTML][HTML] TRIM3 inhibits P53 signaling in breast cancer cells
X Wang, Y Zhang, X Pei, G Guo, B Xue, X Duan… - Cancer cell …, 2020 - Springer
… to develop more novel therapeutics targets for luminal type breast cancer patients. … Several
E3 ubiquitin ligases were reported to promote P53 protein ubiquitination and degradation, …
E3 ubiquitin ligases were reported to promote P53 protein ubiquitination and degradation, …
UHRF1 modulates breast cancer cell growth via estrogen signaling
G Luo, Q Li, M Yu, T Wang, Y Zang, Z Liu, Z Niu… - Medical Oncology, 2022 - Springer
… Since very few studies report the E3 ubiquitin ligase function of UHRF1 in modulating
certain signaling pathway, we provide a novel insight in UHRF1 function, which modulates …
certain signaling pathway, we provide a novel insight in UHRF1 function, which modulates …
BCAS3 exhibits oncogenic properties by promoting CRL4A‐mediated ubiquitination of p53 in breast cancer
Z Zhou, R Qiu, W Liu, T Yang, G Li, W Huang… - Cell …, 2021 - Wiley Online Library
… In addition to MDM2, Cullin4A-RING E3 ubiquitin ligase (CRL4A) could interact with and …
a novel prognostic marker and guides chemotherapy regimens for patients with breast cancer. …
a novel prognostic marker and guides chemotherapy regimens for patients with breast cancer. …
[HTML][HTML] RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer
S Wang, H Luo, C Wang, H Sun, G Sun, N Sun… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… The E3 ubiquitin ligases ring finger protein 8 (RNF8) has been reported as a 485-amino …
Our study describes a novel function of RNF8 on modulation of ERα action in addition to its role …
Our study describes a novel function of RNF8 on modulation of ERα action in addition to its role …