… can help in the development of novel therapeutics. … Thus, E3 ubiquitin ligases are ideal
targets for cancer. One of … Breast Cancer-1 (BRCA1) is a protein involved in breast and …

… Breast cancer metastasis suppressor 1 … -Cul3 ubiquitin ligase. BTB domain-mediated SPOP
dimerization recruits two copies of Cul3-RBX1 to form a dimeric SPOP-Cul3 ligase complex …

… In this study, we uncovered the biological functions and a novel regulatory mechanism of
CRL4 E3 ligase in cancer chemotherapy resistance. We found that CRL4 was upregulated in …

… For instance, it has been confirmed that Parkin targets lysine 477 on HIF-1α for ubiquitination
and degradation to prevent breast cancer cell migration and invasion [78]. Therefore, it is …

… roles of selected E3s and highlights novel opportunities for therapeutic intervention. …
BRCA1 in breast cancer and ovarian cancer 56 . Large-scale analyses of cancer genomes have …

… progression in ERα-positive breast cancer cells [8]. In colorectal … of E3 ubiquitin ligase
RBCK1 in ovarian cancer and its relationship with PTEN. We hypothesize that RBCK1 has a novel …

… drugs on breast cancer cells, thus inhibiting NF-κB activity [218]. Although the β-TrCP …
can be a feasible strategy to screen and develop novel E3 ligase inhibitors for tumor therapy…

… Our study revealed a novel nongenomic regulatory relationship between TRIM3 and ER …
putative E3 ubiquitin ligase, we further investigated the role of TRIM3 in ER alpha ubiquitination. …

… in breast cancer cells inhibits breast cancer growth in athymic mice. We also find that RNF20/40
and Eg5 are concurrently upregulated in human breast cancer … A, or B, breast cancer. …

… In addition, the effect of RAPTA complexes on breast cancer susceptibility gene 1 (… RING
domain result in a loss of the E3 ubiquitin ligase activity leading to hypersensitivity of cancer …