[HTML][HTML] The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ

JM Lee, SS Choi, YH Lee, KW Khim, S Yoon… - … & molecular medicine, 2018 - nature.com
… In this study, we demonstrate that a novel E3 ligase of PPARγ… defined as E3 ubiquitin ligases,
as they contain a ring-finger … estrogen with respect to breast cancer as a primary response …

Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance

H Wang, Y Lu, M Wang, Y Wu, X Wang, Y Li - Journal of Molecular …, 2021 - Springer
… tumor suppressive roles of E3 ligases in GC carcinogenesis and focus on the effects of E3
ligases on cisplatin resistance in GC cells, which will provide novel therapeutic targets for GC …

Cullin 7 in tumor development: a novel potential anti-cancer target.

LI Yumiao, Z Aiming, FU Jiejun, JIA Youchao - Neoplasma, 2021 - search.ebscohost.com
… Overexpressed ubiquitin ligase Cullin7 in breast cancer promotes cell proliferation and
invasion via down-regulating p53. Biochem Biophys Res Commun 2014; 450: 1370–1376. https://…

Protein knockdown technology: application of ubiquitin ligase to cancer therapy

N Ohoka, N Shibata, T Hattori… - Current Cancer Drug …, 2016 - ingentaconnect.com
… advanced or metastatic breast cancer in the event … novel type of SERD, and may become
an alternative to these conventional drugs for patients with hormone-responsive breast cancer

The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple‐negative breast cancer cells

B Pereira De Carvalho, YJ Chern, J He… - FEBS letters, 2021 - Wiley Online Library
… Our study suggests a potential novel role for RNF8 in mediating cell … ligases XIAP [[45]] and
FBXL19 [[46]]. Unlike the previously reported downregulation caused by E3 ubiquitin ligases, …

[HTML][HTML] Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA

A Subramanian, A Andronache, YC Li, M Wade - Oncotarget, 2016 - ncbi.nlm.nih.gov
… abrogated by inhibition of the mitochondrial RING E3 ligase, MARCH5. Mechanistically, this
… in MCL1-dependent breast cancer cells. Our data uncover a novel level at which the BCL2 …

[HTML][HTML] GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis

H Yin, Q Zhu, M Liu, G Tu, Q Li… - International …, 2017 - spandidos-publications.com
breast cancer cells. Thus, the present study provides a novel insight to TAM-resistance in
ER-positive breast cancer … the subfamilies of the RING type E3 ubiquitin ligases), are involved …

Identification of target analogues of E3 ubiquitin ligase involved in the incidence of breast cancer: A rational drug designing approach

S Kumari, P Narad, A Sengupta - … International Conference on …, 2018 - ieeexplore.ieee.org
E3 ubiquitin ligase is responsible for the disease. In this study the interaction of the protein
E3 ubiquitin and … This study reveals that novel compounds are produced with high affinity for …

The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases

X Chen, J Ma, Z Wang, Z Wang - Seminars in Cell & Developmental …, 2024 - Elsevier
E3 ubiquitin ligases to alleviate cardiovascular diseases. Therefore, modulation of E3 ubiquitin
ligases could be a novel … inhibition of cell growth in breast cancer cells. Moreover, Nrdp1 …

[HTML][HTML] Functional roles of E3 ubiquitin ligases in gastric cancer

M Wang, W Dai, Z Ke, Y Li - Oncology Letters, 2020 - spandidos-publications.com
… cell proliferation in osteosarcoma, breast cancer, prostate cancer and lung cancer in vitro
and in … APG115 has been identified as a novel inhibitor of MDM2 ligase, and its potential for …