… Ring finger protein 181 (RNF181) belongs to RING finger protein family, and functions as an
E3 ubiquitin ligase … Our study provided a novel insight into the post-translational mechanism …

… and how targeting E3 ubiquitin ligases acts a novel strategy for bladder cancer therapy. …
growth in animal models of bladder cancer, liver cancer, lung cancer, breast cancer and ovarian …

… The final step of the ubiquitination cascade is regulated by Ub ligases (E3s), … the ubiquitination
of a given substrate [30]. RING-type Ub ligases are thus far the only ubiquitin ligases that …

… chemists to design novel binders of E3 ubiquitin ligases. By taking … focus on E3 ubiquitin
ligases as possible cancer targets; The … carcinoma, small cell lung carcinoma, breast cancer and …

… -positive breast cancer patients. In the present study, we identify a novel E3 ubiquitin ligase
… TRIM11 is overexpressed in human breast cancer, and associates with poor prognosis. The …

… breast cancer and provides potential targets for developing novel therapeutic targets for
breast cancer… TRIM58 belongs to the E3 ubiquitin ligase and typically interacts with target …

… Furthermore, we investigated whether the E3 ubiquitin ligase activity of BCA2 is needed for
… for LPS-induced NF-κB signaling pathway activation independent of its E3 ligase activity. …

… In the present study, with a label-free quantitative proteomic approach, TNFAIP1 was
identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase (CRL) complex. More …

… ubiquitin ligase SMURF1 associates with and stabilizes ER alpha protein in the cytoplasm in
breast cancer … In conclusion, our study reveals a novel positive feedback between SMURF1 …

… ) [34], and contributes to the E3 ubiquitin ligase activity of PRC1 via binding to the catalytic
… mediated through BMI1's ring finger (RF) domain [9,16,35,48,54]. The E3 ligase activity is an …