Novel approaches to the management of noneosinophilic asthma

NC Thomson - Therapeutic advances in respiratory disease, 2016 - journals.sagepub.com
… in asthma and assesses clinical trials of licensed drugs, novel … in noneosinophilic asthma
than eosinophilic asthma. Noneosinophilic … is reported in neutrophilic asthma. Neutrophilia in …

Latrophilin receptors: novel bronchodilator targets in asthma

A Faiz, C Donovan, MAE Nieuwenhuis… - Thorax, 2017 - thorax.bmj.com
… a novel role for latrophilin (LPHN) receptors, finding increased expression on ASMC from
asthmatics, compared with non-asthmatics in … was associated with asthma and with increased …

A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma

V Swystun, FHY Green, JH Dennis, E Rampakakis… - Trials, 2018 - Springer
… This study evaluates a novel bronchodilator, S1226, for its efficacy in reversing allergen-…
in subjects with mild, allergic asthma. S1226 is a new class of bronchodilator that is an aerosol/…

The future of bronchodilation: looking for new classes of bronchodilators

M Cazzola, P Rogliani… - European Respiratory …, 2019 - Eur Respiratory Soc
… the pharmaceutical industry in developing novel bronchodilators. There are several new …
from asthmatic patients [75]. It has been documented that the sputum from asthmatic patients …

[HTML][HTML] A novel in vivo system to test bronchodilators

KJ Addison, J Morse, A Robichaud… - Journal of infectious …, 2017 - ncbi.nlm.nih.gov
… Fast acting drugs, such as albuterol, or novel therapeutic treatments for asthma have been
… drugs can be reproducibly tested to advance the development of novel asthma therapeutics. …

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma

NC Thomson - Expert opinion on pharmacotherapy, 2017 - Taylor & Francis
… developing effective novel small molecule drugs for asthma will … and the different phenotypes
and endotypes of asthma. … with symptomatic asthma and a pre-bronchodilator FEV 1 of 60–…

Transforming growth factor-β1: a novel cause of resistance to bronchodilators in asthma?

MA Wortley, SJ Bonvini - American Journal of Respiratory Cell and …, 2019 - atsjournals.org
… and novel study reveals a mechanism by which resistance to the effects of bronchodilators
may … bronchodilator effects. If future research confirms these findings in the context of severe …

New avenues for phosphodiesterase inhibitors in asthma

MG Matera, J Ora, F Cavalli, P Rogliani… - Journal of …, 2021 - Taylor & Francis
asthma mainly for PDE3, PDE4, PDE5 and PDE7. Consequently, drugs that inhibit PDEs may
offer novel … on treatment especially in severe asthma due to their bronchodilator and/or anti-…

Elucidating novel disease mechanisms in severe asthma

RY Kim, B Rae, R Neal, C Donovan… - Clinical & …, 2016 - Wiley Online Library
novel murine models of respiratory infection-induced, severe, steroid-resistant asthma that
… low pre-bronchodilator FEV 1 and high post-bronchodilator response; second cluster with …

Application of nano-and micro-particle-based approaches for selected bronchodilators in management of asthma

S Singh, N Sharma, J Gupta, A Kyada, D Nathiya… - 3 Biotech, 2024 - Springer
… Recently, there have been advancements in the development of novel medications for
asthma therapy. In addition, there have been enhancements in the administration methods of …