New treatment option for chronic obstructive pulmonary disease: two long-acting bronchodilators in a single metered-dose inhaler

TH Self, S Ellingson - The American Journal of Medicine, 2017 - Elsevier
… of 2 long-acting bronchodilators in a pressurized metered-dose inhaler (MDI) is novel (see …
Unfortunately, it is well documented that 5%-18% (ie, several million) of COPD and asthma

Abediterol, a novel long-acting β2-agonist: bronchodilation, safety, tolerability and pharmacokinetic results from a single-dose, dose-ranging, active-comparator study …

J Beier, H Pujol, B Seoane, E Jimenez, C Astbury… - BMC Pulmonary …, 2016 - Springer
novel, once-daily long-acting β 2 -agonist in development for the treatment of chronic obstructive
pulmonary disease (COPD) and asthma … study investigated the bronchodilation, safety, …

A randomized trial of dual-acting bronchodilator AZD8871 for chronic obstructive pulmonary disease

D Singh, R Fuhr, L Jimenez… - American Journal of …, 2019 - atsjournals.org
Long-acting bronchodilators are recommended as maintenance … in longer studies and with
active comparators is warranted to evaluate its potential as a novel treatment option in COPD. …

How do dual long-acting bronchodilators prevent exacerbations of chronic obstructive pulmonary disease?

KM Beeh, PR Burgel, FME Franssen… - American journal of …, 2017 - atsjournals.org
COPD, the relation between mechanical factors and inflammation is supported by results
from studies of patients with asthma, … in COPD: a novel phenotype. PLoS One 2012;7:e37483. …

Optimization of Long-Acting Bronchodilator Dose Ratios Using Isolated Guinea Pig Tracheal Rings for Synergistic Combination Therapy in Asthma and COPD

E Menchi, C El Khattabi, S Pochet, O Denis, K Amighi… - Pharmaceuticals, 2022 - mdpi.com
… of a long-acting β2-agonist (LABA), and a long-acting … , such as asthma and chronic obstructive
pulmonary disease (COPD). … therapeutic approaches in asthma and COPD. The synergy …

Long-acting muscarinic antagonists under investigational to treat chronic obstructive pulmonary disease

J Ora, A Coppola, M Cazzola, L Calzetta… - Journal of …, 2020 - Taylor & Francis
… program for a novel LAMA to treat patients with COPD. AZD9164 is a potent … asthma and
moderate to severe COPD and also to assess the ability of AZD/LAS to produce bronchodilation

[PDF][PDF] Optimal bronchodilation for COPD patients: are all long-acting β2-agonist/long-acting muscarinic antagonists the same?

M Miravitlles, S Baek, V Vithlani… - … and respiratory diseases, 2018 - synapse.koreamed.org
Long-term safety and efficacy of glycopyrrolate/formoterol metered dose inhaler using novel
… by patients with asthma and COPD. J Aerosol Med Pulm Drug Deliv 2008;21:321-8. 76. …

Ultra long-acting β-agonists in chronic obstructive pulmonary disease

RM Burkes, RJ Panos - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
… Citation41 To date, vilanterol is only marketed in combination with other COPD/asthma
Abediterol is a novel, long-acting β 2 agonist synthesized by medicinal chemists at Almirall. …

Triple therapy versus single and dual long-acting bronchodilator therapy in COPD: a systematic review and meta-analysis

M Cazzola, P Rogliani, L Calzetta… - European Respiratory …, 2018 - Eur Respiratory Soc
… therapy in chronic obstructive pulmonary disease. The ICS/… compared to single long-acting
bronchodilator therapy. The … patients on single long-acting bronchodilator therapy or LABA/…

Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events

S Suissa, S Dell'Aniello, P Ernst - European Respiratory …, 2017 - Eur Respiratory Soc
… β 2 -agonists (LABAs) and anticholinergics (LAMAs) in COPD is uncertain. We assessed the
… a second long-acting bronchodilator in patients with COPD. We identified a cohort of COPD