… cardiovascular and cerebrovascular safety of inhaled longacting bronchodilators in patients with chronic obstructive pulmonary disease: a population‐based cohort …

YH Dong, CH Chang, JJ Gagne… - … : The Journal of …, 2016 - Wiley Online Library
… between COPD and asthma, we excluded patients who also had … COPD is not appropriately
controlled with monotherapy.7 Recently, several novel inhaled long-acting bronchodilators

A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD

L Calzetta, P Rogliani, MG Matera, M Cazzola - Chest, 2016 - Elsevier
… Overall forest plot meta-analysis of the impact of long-acting muscarinic antagonist/long-acting
β2-agonist combinations on trough FEV 1 and subgroup analysis performed on lower and …

[HTML][HTML] … of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholine-induced bronchoconstriction in mild asthmatics

CM Blais, BE Davis, DW Cockcroft - Respiratory medicine, 2016 - Elsevier
… As previously mentioned, the two drugs investigated in this study are typically used in COPD
patients and as such have more research data in that patient population. Glycopyrronium …

[HTML][HTML] Small airway inflammation and extrafine inhaled corticosteroids plus long-acting beta2-agonists formulations in chronic obstructive pulmonary disease

P Pirina, MPF Barbaro, D Paleari, A Spanevello - Respiratory Medicine, 2018 - Elsevier
… include long-acting inhaled bronchodilators (long-acting beta 2 -… COPD mainly for prediction
of exacerbations and the need for ICS. As with asthma, FeNO levels in patients with COPD

… controlled trial of long-acting muscarinic antagonist and long-acting β2 agonist fixed-dose combinations in patients with chronic obstructive pulmonary disease

M Muraki, Y Kunita, K Shirahase, R Yamazaki… - BMC Pulmonary …, 2021 - Springer
chronic obstructive pulmonary disease (COPD) patients, combination treatment with long-acting
muscarinic antagonist (LAMA) and long-actingasthma could be enrolled, if the asthma

Effects of long-acting bronchodilators on cardiac autonomic control in COPD

S Elhage, L Laurent, K Diallo, M Bouhaddi… - … Medicine and Research, 2022 - Elsevier
… cardiovascular control in COPD patients. Further investigations are needed to explore
mechanisms by which long-acting bronchodilators may increase cardiovascular events in COPD. …

… , parallel-group phase 3 trial to evaluate the safety and tolerability of a nebulized long-acting muscarinic antagonist (Revefenacin) in study participants with COPD

L DeLaCruz, S Pendyala, C Barnes, E Moran… - Chest, 2016 - journal.chestnet.org
… CLINICAL IMPLICATIONS: Nebulized once-daily revefenacin, a novel LAMA in development
for the treatment of COPD, may be an important future treatment option, subject to the …

Comparative efficacy of long-acting β2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis

JF Donohue, KA Betts, EX Du, P Altman… - … obstructive pulmonary …, 2017 - Taylor & Francis
bronchodilators. Citation1 LABA monotherapy is contraindicated for patients with asthma, …
the comparative efficacy of long-acting bronchodilators for COPD found that indacaterol was …

[HTML][HTML] … antagonist for nebulized therapy: safety and tolerability results of a 52-week phase 3 trial in moderate to very severe chronic obstructive pulmonary disease

JF Donohue, E Kerwin, S Sethi, B Haumann… - Respiratory …, 2019 - Elsevier
… ) bronchodilators as first-line therapy to address disease symptoms and to prevent exacerbations
in patients with chronic obstructive pulmonary disease (COPD). … Revefenacin, a novel, …

[HTML][HTML] Understanding the role of long-acting muscarinic antagonists in asthma treatment

S Muiser, R Gosens, M van den Berge… - … of Allergy, Asthma & …, 2022 - Elsevier
… In addition, it would be useful to perform a study in a large population of patients with
asthmachronic obstructive pulmonary disease overlap, in which we would expect good …