… To test this hypothesis, we first evaluated the influence of GRHL2 … We validated a subset of
these biological associations. … There is an urgent requirement for novel strategies that inhibit …

… The rational discovery of novel drug combinations can be … novel and unexpected synergistic
drug combinations 19, 39. … assist in generating biologically meaningful MOA hypotheses for …

… to support drug development, by generating hypotheses that can be tested experimentally in
pre-… known biological mechanisms. We identify the most effective treatment combinations for …

… , and design novel therapeutic and preventive strategies. … The current drug development
pipeline still strongly relies on … is based on experimental hypotheses formulated during basic/…

… to identify novel anticancer targets and discover drugs. … based on the experimentally
validated hypothesis that can … used the differentially expressed proteins of prostate cancer (PC…

… treatment could be a novel strategy in managing patients … This prior trial had an early close,
owing to drug development … should be regarded rather as hypothesis-generating. They must …

… We review the biology of advanced prostate cancer, and highlight opportunities and challenges
for using biological or molecular assays to help guide individualized treatment decisions …

… While these hypotheses are currently less well … drugs and novel vaccines to combat
SARS-CoV-2 infection, as well as repurposed drugs that could have an impact on prostate cancer …

… the biological activity of FABP5, the availability of highly effective inhibitors to FABP5 is
an important first step in testing this hypothesis. … In this work, we have used the novel bio-inhibitor …

… more importantly the pursuit of understanding biological complexities. In our laboratory…
hypothesis was that targeting both PAK4 and NAMPT could become a synthetic lethal strategy for …