… + release from InsP 3 R2 present at the perinuclear SR and the nuclear envelope stimulates
nuclear Ca 2+ signaling pathways. (3) β-Adrenergic receptor (β-AR) activation leads to the …

… In this article, we (1) review cytosolic and nuclear Ca 2+ dynamics in cardiomyocytes with …
cardiomyocytes and their role in cardiac disease. First, we discuss cytosolic and nuclear Ca 2+ …

… In the heart, Ca 2+ signals regulate a variety of biological functions … In this review, we
summarize the role of local Ca 2+ … by local nuclear Ca 2+ levels set by release of Ca 2+ from …

… can modulate perinuclear Ca 2+ handling of the cardiomyocytes (… nuclear Ca 2+ release, we
examined whether the nuclear … regulate SERCA-based Ca 2+ uptake into the nuclear Ca 2+ …

… inhibition on perinuclear/nuclear Ca 2 + uptake and release in CMs. Anti-PLB-Fab, covalently
linked to Alexa-594, most heavily immunolabeled SR [10] and NE of mouse CM (Fig. 6A). …

… Therefore, we elucidated cellular mechanisms underlying nuclear Ca 2 + regulation in LV
… the major Ca 2 + -regulating proteins in LV tissue lysates and isolated cardiomyocyte nuclei …

… -mediated nuclear retention of HDAC4 was modified by changes in [Ca 2+ ] o which could
alter CaMKII activity, we incubated cardiomyocytes in NT solution containing different [Ca 2+ ] …

… Ca 2+ prevented calcineurin-dependent NFATc nuclear translocation and myocyte hypertrophy,
without affecting cardiac myocyte … Additional findings suggest that the perinuclear Ca 2+ …

… As an illustrative example, we will consider the processes by which nuclear but not cytosolic
Ca 2+ regulates nuclear CaMKII that in turn phosphorylates the transcriptional regulator …

… relevance of nuclear NCX in controlling [Ca 2+ ] n and some important functions regulated
by … of hypertrophic gene program in cardiomyocytes [68]. Very interestingly, normalization of …