Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient

M Shimojima, S Yuasa, C Motoda, G Yozu, T Nagai… - Scientific reports, 2017 - nature.com
nuclear Ca 2+ homeostasis. The aim of this study is to elucidate the role of emerin in rat
cardiomyocytes … is involved in nuclear Ca 2+ signaling in cardiomyocytes and participates in the …

Inositol trisphosphate receptors and nuclear calcium in atrial fibrillation

XY Qi, F Vahdati Hassani, D Hoffmann, J Xiao… - Circulation …, 2021 - Am Heart Assoc
… In this study, we tested the effects of AF on atrial-cardiomyocyte nuclear Ca 2+ and related …
-cardiomyocyte Ca 2+ -handling to increase nuclear Ca 2+ -load by IP 3 R1-dependent Ca 2+ …

Crosstalk between FGF23- and angiotensin II-mediated Ca2+ signaling in pathological cardiac hypertrophy

KN Mhatre, P Wakula, O Klein, E Bisping… - Cellular and Molecular …, 2018 - Springer
… common mechanism of IP3-nuclear Ca 2+ -dependent cardiomyocyte hypertrophy. FGF23-…
of ATII by cardiomyocytes. These findings indicate a pathophysiological role of the cellular …

Calcium signaling in the heart

DA Terrar - Calcium Signaling, 2020 - Springer
Ca 2+ -stimulated enzyme in cardiac myocytes is the Ca 2+ and … central to Ca 2+ -dependent
regulation of cardiac function and has … Evidence concerning IP 3 -dependent nuclear Ca 2+ …

GDF11 Modulates Ca2+-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy

J Duran, MF Troncoso, D Lagos, S Ramos… - International Journal of …, 2018 - mdpi.com
… + pathways were involved in Smad2/3 activation by GDF11, we examined whether nuclear
translocation of Smad2/3 was dependent on Ca 2+ -dependent pathways. To this end, …

Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

P Robinson, X Liu, A Sparrow, S Patel… - Journal of Biological …, 2018 - ASBMB
… + /calmodulin-dependent protein kinase II (CaMKII), calcineurin/nuclear factor of activated …
cardiomyocyte function, we compared the contractility and Ca 2+ transients of cardiomyocytes

The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation

X Wang, X Chen, D Dobrev, N Li - Pflügers Archiv-European Journal of …, 2021 - Springer
… influenced by the altered functions of Ca 2+ -handling proteins in cardiomyocytes. EADs are
… + -induced calcineurin (CaN)-mediated activation of NFAT (nuclear factor of activated T-cell)…

Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin

T Oda, T Yamamoto, T Kato, H Uchinoumi… - Journal of molecular and …, 2018 - Elsevier
… importantly regulate RyR2 gating in cardiac myocytes, the role … structural and functional
changes in the nuclear envelope … the nucleoplasmic Ca 2+ handling (increasing diastolic [Ca 2+ …

The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca2+ Channels and Mitochondrial Function in Cardiomyocytes

S Mahmoodzadeh, E Dworatzek - Frontiers in Endocrinology, 2019 - frontiersin.org
… sex-disparity in nuclear shuttling of α1C-dCT in mouse cardiomyocytes (164). Here, the
nuclear shuttling was significantly higher in isolated female cardiomyocytes compared to males. …

Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts

L Han, JD Mich-Basso, Y Li, N Ammanamanchi, J Xu… - Developmental cell, 2022 - cell.com
Nuclear pores are essential for nuclear-cytoplasmic transport… nuclear pores to alter nuclear
transport and cellular function … (cardiomyocytes) undergo a 63% decrease in nuclear pore …