[HTML][HTML] Ginsenoside Rb3 upregulates sarcoplasmic reticulum Ca2+-ATPase expression and improves the contractility of cardiomyocytes by inhibiting the NF-κB …

M Shao, P Gao, W Cheng, L Ma, Y Yang, L Lu… - Biomedicine & …, 2022 - Elsevier
… and myocardial function. In vivo, we found that G-Rb3 decreased the levels of both nuclear
factor … protein I (cTnI) and α-actinin) to improve cardiac function. G-Rb3 inhibited NF-κB p65 …

How cardiomyocytes sense pathophysiological stresses for cardiac remodeling

ZK Haque, DZ Wang - Cellular and Molecular Life Sciences, 2017 - Springer
… Extracellular stimuli increase intracellular Ca 2+ levels by either promoting its release from
… Given the location of CIP and LMNA on the nuclear envelope, we propose that they respond …

Role of mitochondrial Ca2+ homeostasis in cardiac muscles

JL Cao, SM Adaniya, MW Cypress, Y Suzuki… - Archives of biochemistry …, 2019 - Elsevier
… mechanisms for mitochondrial Ca 2+ handling in cardiomyocytes and its contribution to …
Later, a study using nuclear magnetic resonance proposed a pentameric homo-oligomer [42…

A balance between intermediate filaments and microtubules maintains nuclear architecture in the cardiomyocyte

J Heffler, PP Shah, P Robison, S Phyo, K Veliz… - Circulation …, 2020 - Am Heart Assoc
cardiomyocyte hypertrophy and eventually heart failure. While several force-dependent
signaling cascades that regulate cardiomyocyte … the nesprins (nuclear envelope spectrin repeat …

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

M Eden, B Meder, M Völkers, M Poomvanicha… - Nature …, 2016 - nature.com
Ca 2+ amplitudes and a lower diastolic Ca 2+ … function could be attributed to Myoscape/FAM40B.
We now provide evidence that Myoscape plays a key role in regulating cardiomyocyte

The control of diastolic calcium in the heart: basic mechanisms and functional implications

DA Eisner, JL Caldwell, AW Trafford… - Circulation …, 2020 - Am Heart Assoc
… + ] i increases, buffering power will decrease so a given increase in [Ca 2+ ] i will require
a smaller increase in total Ca 2+ (for review, see the article by Smith and Eisner 3 ). In other …

PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes

I Bedioune, F Lefebvre, P Lechêne… - Cardiovascular …, 2018 - academic.oup.com
… mechanisms by which β 1 - and β 2 -ARs regulate nuclear PKA activity in cardiomyocytes. …
ARs differentially regulate nuclear PKA activity and ICER expression in cardiomyocytes. PDE4 …

[HTML][HTML] MED12 regulates a transcriptional network of calcium-handling genes in the heart

KK Baskin, CA Makarewich, SM DeLeon, W Ye… - JCI insight, 2017 - ncbi.nlm.nih.gov
… (Figure 1E), we measured Ca 2+ flux in CMs isolated from … We performed ChIP on nuclear
fractions of CMs isolated from … Cardiomyocyte relaxation is regulated by signaling pathways …

Calcium inhibitor inhibits high glucose‑induced hypertrophy of H9C2 cells

X Xu, L Ruan, X Tian, F Pan… - Molecular Medicine …, 2020 - spandidos-publications.com
… The role of the Ca2+-calcineurin (CaN)-nuclear factor of activated T cells 3 (NFAT3) …
Norvasc could induce the recovery of cardiomyocyte hypertrophy and inhibit Ca2+-CaN-NFAT3 …

Dedifferentiation, proliferation, and redifferentiation of adult mammalian cardiomyocytes after ischemic injury

WE Wang, L Li, X Xia, W Fu, Q Liao, C Lan, D Yang… - Circulation, 2017 - Am Heart Assoc
… cells with cardiomyocyte contractile function. Intercellular propagation of Ca 2+ from …
cells was required to activate the Ca 2+ -dependent calcineurin-nuclear factor of activated T-cell …