… of neuroinflammation imaging with (R)-[ 11 C]PK11195 (… first systematic review of these
“(R)-[ 11 C]PK11195 challengers”, … a number of detailed reviews [32,33,34], no meta-analysis is …

… Subsequent studies [ 11 C](R)-PK11195 have been successfully conducted for diseases as
… ] (see [13–15] for review). Quantitative analysis of [ 11 C](R)-PK11195 in AD patients showed …

… be biased by increased [ 11 C](R)PK11195 nonspecific binding and suggested that [ 11 C](R)PK11195
PET may not be robust enough to assess the extent of neuroinflammation in vivo (…

… While [ 11 C](R)-PK11195 is the most highly represented … While no association between [
11 C](R)-PK11195 binding and … an increase in [ 11 C](R)-PK11195 binding correlated with an …

… radiolabeling is a complex process, and the half-life of carbon-11 is just 20 min long; thus,
[ 11 C]-PK11195 could only be used in PET centers equipped with cyclotrons [16]. Second, [ …

… immune cells and neuroinflammation (8,10). The first TSPO PET tracer to be widely evaluated
for imaging neuroinflammation was 11 C-PK11195. Although 11 C-PK11195 provided an …

… ligand PK11195 that could be radiolabelled with [ 11 C] led to a long series of positron
emission tomography (PET) investigations in a broad range of neurological conditions [7,8,9,10,…

… In our own group study of 12 MCI compared with 7 healthy volunteers, ROI analysis revealed
increased 11 C-(R)-PK11195 binding in the posterior cingulate gyrus, parietal, occipital, …

… Here, we report results comparing the recently developed TSPO tracers [ 18 F]GE-180
and [ 18 F]DPA-714 with (R)-[ 11 C]PK11195 in a rodent model of subtle focal inflammation. …

… activation with 11 C-PK11195 PET imaging indeed showed … Several studies confirmed
an increased 11 C-PK11195 … for the quantification of the 11 C-PK11195 uptake [76,83,84]. …