… with very low total T4 and highly elevated TSH. Probably, this small fibrous thyroid gland
with a low iodine intake and accelerated iodine metabolism might rapidly lose its limited iodine …

… If selenium deficiency coexists with iodine deficiency, this reduces D2 … Iodine is essential
for thyroid hormone synthesis and must be provided through dietary sources. Thyroid hormone …

… the role of iodine in TH biosynthesis and define the detrimental consequences of iodine …
, such as selenium and iron, required for the optimal function of key enzymes involved in TH …

… In the thyrocytes, the thyroid hormones biosynthesis is carried out by iodization of tyrosine
to T3 and T4. Secretion of T3 and T4 is regulated by TSH. On the tissue level, the active …

… They are important for (brain) growth and metabolism and protect against free radicals and …
the role of iodine in the formation of thyroid hormones is well established, the role of selenium …

… In a study conducted in a Danish area with mild iodine deficiency, Se deficiency is associated
with thyroid gland volume and nodule formation before and after introduction of iodine …

… Hereby, we want to elucidate how a low selenium supply affects the thyroid gland itself but
… by the limited iodine supply. In addition, interactions of the selenium and iodine supply with …

… biosynthesis of THs. A deficiency of DEHAL1 leads to hypothyroidism, if the loss of iodine …
accumulation of the selenium compounds in the thyroid gland may restrict their applicability. …

… Selenium is a component of several … regulate thyroid hormone synthesis and protect the
thyroid gland from oxidative stress. An important function of selenium is its interaction with iodine …

… of thyroid hormone biosynthetic pathways depends not only on the specificity of iodine
metabolism … Interestingly, TSH and selenium have also been shown to cooperate and upregulate …