Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer's …
… inform cognitive impairment. We have utilised the 5xFAD transgenic mouse model that … of
male and female 5xFAD mice, we examined amyloid plaque deposits in brain sections stained …
male and female 5xFAD mice, we examined amyloid plaque deposits in brain sections stained …
Intact olfactory memory in the 5xFAD mouse model of Alzheimer's disease from 3 to 15 months of age
TP O'leary, KR Stover, HM Mantolino, S Darvesh… - Behavioural Brain …, 2020 - Elsevier
… -onset impairments in very long-term (remote) memory have … female 5xFAD mice do not
develop olfactory memory deficits, … deposition within the olfactory-memory regions of the brain. …
develop olfactory memory deficits, … deposition within the olfactory-memory regions of the brain. …
Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments
TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
… Transgenic mouse models are commonly used to examine the neurobiological basis of …
systems of the brain and spinal cord, the 5xFAD mice exhibit motor impairments beginning at 9 …
systems of the brain and spinal cord, the 5xFAD mice exhibit motor impairments beginning at 9 …
[HTML][HTML] The 5XFAD mouse model of Alzheimer's disease displays age-dependent deficits in habituation to a novel environment
S Smith, SC Hopp - Aging Brain, 2023 - Elsevier
… readout for hippocampal-dependent memory deficits that are … time, while 5XFAD mice
displayed age-dependent deficits in … field data from 5XFAD and late-onset AD mouse models with …
displayed age-dependent deficits in … field data from 5XFAD and late-onset AD mouse models with …
Conditional BDNF delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xFAD mouse model of Alzheimer disease
B de Pins, C Cifuentes-Díaz, AT Farah… - Journal of …, 2019 - Soc Neuroscience
… endogenous biomarkers with early onset, such as astrogliosis, … -BDNF mice with the 5xFAD
transgenic mouse model of AD … BDNF hippocampal levels in WT, pGFAP-BDNF, 5xFAD, and …
transgenic mouse model of AD … BDNF hippocampal levels in WT, pGFAP-BDNF, 5xFAD, and …
Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model
S Kang, J Kim, KA Chang - Scientific Reports, 2021 - nature.com
… hippocampus of 6xTg mice beginning at 2 months. In 6xTg … , we crossed 5xFAD mice with
JNPL3 mice, the animal model of … For our study, we made JNPL3 hemizygous transgenic mice …
JNPL3 mice, the animal model of … For our study, we made JNPL3 hemizygous transgenic mice …
The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer's Disease
M Migliorati, C Manrique, M Rahrah… - … of Alzheimer's …, 2022 - content.iospress.com
… Several transgenic mouse models have been used for this … The onset of visible Aβ deposits
varies across mouse models… of hippocampal-dependent long-term memory impairments [15]. …
varies across mouse models… of hippocampal-dependent long-term memory impairments [15]. …
Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model
Y Li, K Zhu, N Li, X Wang, X Xiao, L Li, L Li… - Alzheimer's Research & …, 2021 - Springer
… of hippocampal CA1 pyramidal neurons in 5XFAD mice using … mild cognitive impairments
in 5XFAD transgenic mice. Further … from − 30 to + 30 pA in a duration of 500 ms, and the input …
in 5XFAD transgenic mice. Further … from − 30 to + 30 pA in a duration of 500 ms, and the input …
Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes
E Gür, E Fertan, K Alkins, AA Wong… - Journal of …, 2019 - Wiley Online Library
… of the 5xFAD transgenic mouse model of Alzheimer's disease and … onset transgenic model
of AD co-expresses five transgenes … hippocampus is affected more and/or earlier in the 5xFAD …
of AD co-expresses five transgenes … hippocampus is affected more and/or earlier in the 5xFAD …
Early impairments of hippocampal neurogenesis in 5xFAD mouse model of Alzheimer's disease are associated with altered expression of SOXB transcription factors
… , the adult hippocampal neurogenic niche, in the 5xFAD transgenic … and their appropriate
controls (non-transgenic mice, non-Tg) … 5xFAD mice are known to be an early onset transgenic …
controls (non-transgenic mice, non-Tg) … 5xFAD mice are known to be an early onset transgenic …