Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer's …

CH Poon, STN Wong, J Roy, Y Wang, HWH Chan… - Cells, 2023 - mdpi.com
… inform cognitive impairment. We have utilised the 5xFAD transgenic mouse model that … of
male and female 5xFAD mice, we examined amyloid plaque deposits in brain sections stained …

Intact olfactory memory in the 5xFAD mouse model of Alzheimer's disease from 3 to 15 months of age

TP O'leary, KR Stover, HM Mantolino, S Darvesh… - Behavioural Brain …, 2020 - Elsevier
… -onset impairments in very long-term (remote) memory have … female 5xFAD mice do not
develop olfactory memory deficits, … deposition within the olfactory-memory regions of the brain. …

Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments

TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
Transgenic mouse models are commonly used to examine the neurobiological basis of …
systems of the brain and spinal cord, the 5xFAD mice exhibit motor impairments beginning at 9 …

[HTML][HTML] The 5XFAD mouse model of Alzheimer's disease displays age-dependent deficits in habituation to a novel environment

S Smith, SC Hopp - Aging Brain, 2023 - Elsevier
… readout for hippocampal-dependent memory deficits that are … time, while 5XFAD mice
displayed age-dependent deficits in … field data from 5XFAD and late-onset AD mouse models with …

Conditional BDNF delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xFAD mouse model of Alzheimer disease

B de Pins, C Cifuentes-Díaz, AT Farah… - Journal of …, 2019 - Soc Neuroscience
… endogenous biomarkers with early onset, such as astrogliosis, … -BDNF mice with the 5xFAD
transgenic mouse model of AD … BDNF hippocampal levels in WT, pGFAP-BDNF, 5xFAD, and …

Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model

S Kang, J Kim, KA Chang - Scientific Reports, 2021 - nature.com
hippocampus of 6xTg mice beginning at 2 months. In 6xTg … , we crossed 5xFAD mice with
JNPL3 mice, the animal model of … For our study, we made JNPL3 hemizygous transgenic mice

The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer's Disease

M Migliorati, C Manrique, M Rahrah… - … of Alzheimer's …, 2022 - content.iospress.com
… Several transgenic mouse models have been used for this … The onset of visible Aβ deposits
varies across mouse models… of hippocampal-dependent long-term memory impairments [15]. …

Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model

Y Li, K Zhu, N Li, X Wang, X Xiao, L Li, L Li… - Alzheimer's Research & …, 2021 - Springer
… of hippocampal CA1 pyramidal neurons in 5XFAD mice using … mild cognitive impairments
in 5XFAD transgenic mice. Further … from − 30 to + 30 pA in a duration of 500 ms, and the input …

Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes

E Gür, E Fertan, K Alkins, AA Wong… - Journal of …, 2019 - Wiley Online Library
… of the 5xFAD transgenic mouse model of Alzheimer's disease and … onset transgenic model
of AD co-expresses five transgeneshippocampus is affected more and/or earlier in the 5xFAD

Early impairments of hippocampal neurogenesis in 5xFAD mouse model of Alzheimer's disease are associated with altered expression of SOXB transcription factors

I Zaletel, M Schwirtlich, M Perović… - … of Alzheimer's …, 2018 - content.iospress.com
… , the adult hippocampal neurogenic niche, in the 5xFAD transgenic … and their appropriate
controls (non-transgenic mice, non-Tg) … 5xFAD mice are known to be an early onset transgenic