… In humans, 11β-HSD1 ontogeny is less well characterized with few published studies. Cortisone
… Ex vivo assays using bone chips have shown bidirectional interconversion of cortisone …

… , to investigate the role of interconversion of cortisol and its inactive metabolite cortisone on
… hormone in humans, is essential for normal fetal development and tissue maturation. Fetal …

… subdivided into a trophoblast layer and a connective tissue layer adjacent to the amnion. The
… cortisone inhibit LOX expression in human amnion fibroblasts, and the effect of cortisone is …

… the interconversion of active cortisol to inactive cortisone in humans, maintain a dynamic,
balanced tissue … Ontogeny and nutritional programming of adiposity in sheep: potential …

… its occurrence, metabolism, ontogeny, immunomodulatory activity, … Additional knowledge
about this steroid may elucidate its role in … These important interconversions locally controlling …

… Human amnion tissue and cultured amnion tissue explants … Cortisone also decreased
COL3A1 protein, which was blocked … Here, we examined this hypothesis in human amnion tissue …

… by markedly elevated cortisol:cortisone metabolites in urine [14]. … interconversion of active
cortisol and corticosterone to inert … Distinct ontogeny of glucocorticoid and mineralocorticoid …

… cortisone to active cortisol. We examined whether cortisol regeneration in the amnion might
play a role in human … These results were reproduced in human amnion tissue explants after …

… cortisol, cortisone, and the cortisone-to-(cortisol+cortisone) ratio … cortisol, cortisone, and the
cortisone-to-(cortisol+cortisone) ratio … concentrations in the majority of tissues (31). After birth, …

… a crucial steroid produced locally in the fetal membranes at parturition, and the interaction
between cortisol and SAA1 in the feed-forward induction of SAA1 expression in human … tissue. …