How computational chemistry and drug delivery techniques can support the development of new anticancer drugs
… can give the idea of how computational methods can be used … -GBSA calculations to the
optimization of peptides able to inhibit … for further development of liposomal based formulations. …
optimization of peptides able to inhibit … for further development of liposomal based formulations. …
Trends in drug delivery systems for natural bioactive molecules to treat health disorders: the importance of nano-liposomes
RV Cardoso, PR Pereira, CS Freitas, VMF Paschoalin - Pharmaceutics, 2022 - mdpi.com
… products was prioritized to optimize pharmaceutical production, … Novel delivery concepts
include targeted drug delivery using … success of new nano-liposomal formulations during clinical …
include targeted drug delivery using … success of new nano-liposomal formulations during clinical …
The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di… - Nature reviews drug …, 2018 - nature.com
… strategies for improved formulation and pharmacokinetic and … The effort to increase the
number of druggable targets has … Although analogue optimization is generally recognized as …
number of druggable targets has … Although analogue optimization is generally recognized as …
[PDF][PDF] Development of liposomal formulation: from formulation to sterilization
SM Suthar, BA Rathva - World Journal …, 2019 - wjpr.s3.ap-south-1.amazonaws.com
… various liposomes formulation are in use of medical research because of their fast healing
characteristic. Liposomes with … [17] In view of their length and wide assortment of bilayers, …
characteristic. Liposomes with … [17] In view of their length and wide assortment of bilayers, …
Development of liposome systems for enhancing the PK properties of bivalent PROTACs
P Kou, ES Levy, AD Nguyen, D Zhang, S Chen, Y Cui… - Pharmaceutics, 2023 - mdpi.com
… We developed and characterized liposomal formulations for the … and optimize the EE for
conventional liposomes where … or property resulting from any ideas, methods, instructions or …
conventional liposomes where … or property resulting from any ideas, methods, instructions or …
Strategies for the optimization of natural leads to anticancer drugs or drug candidates
Z Xiao, SL Morris‐Natschke… - Medicinal research …, 2016 - Wiley Online Library
… previous two strategies, this approach has the obvious advantages of enhanced structural
novelty and potentially better chemical accessibility. In a broader view, … to the formulation and …
novelty and potentially better chemical accessibility. In a broader view, … to the formulation and …
Pharmaceutical liposomal delivery—specific considerations of innovation and challenges
T Peng, W Xu, Q Li, Y Ding, Y Huang - Biomaterials science, 2023 - pubs.rsc.org
… Therefore, liposomal technology can improve the druggability of … , and the transition from
concept to clinical application, to provide a … optimization of several parameters to achieve a final …
concept to clinical application, to provide a … optimization of several parameters to achieve a final …
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems
C Sahlgren, A Meinander, H Zhang… - Advanced …, 2017 - Wiley Online Library
… when Doxil, a liposomal anticancer formulation, was introduced… a novel approach, where
the print substrate is optimized for … of new druggable pathways and for preclinical studies to test …
the print substrate is optimized for … of new druggable pathways and for preclinical studies to test …
The new frontiers in neurodegenerative diseases treatment: Liposomal-based strategies
… After optimization of the liposomal formulation, mRNA was administered by intranasal route
to CD-1 mice. Through the GFP and luciferase reporter systems, the authors have quantified …
to CD-1 mice. Through the GFP and luciferase reporter systems, the authors have quantified …
Revolutionizing drug formulation development: the increasing impact of machine learning
… Through the optimization of drug formulations, pharmaceutical … druggability. There are
many examples of pharmaceutical … For example, Vyxeos® is a liposomal formulation, …
many examples of pharmaceutical … For example, Vyxeos® is a liposomal formulation, …