Nanopharmaceuticals to target antifilarials: administration of old age drugs in a novel way
N Joardar, N Mukherjee, SPS Babu - Applications of Nanobiotechnology …, 2021 - Elsevier
… optimization for its bigger efficacy and better pharmacological attires [42]. Furthermore, through
… been made in the liposomal chemistry with the generation of stealth liposomes, targeted …
… been made in the liposomal chemistry with the generation of stealth liposomes, targeted …
Discovery DMPK quick guide
… , we look through the lens of druggability by examining absorption, … Here, we focus on the
application of these concepts during … optimization process with an emphasis on optimization of …
application of these concepts during … optimization process with an emphasis on optimization of …
Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment
… Therefore, further optimization of formulation parameters will … However, owing to a lack of
druggable targets, chemotherapy … The concept of using mitochondria-targeting liposomes for …
druggable targets, chemotherapy … The concept of using mitochondria-targeting liposomes for …
Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective
LG Ferreira, AD Andricopulo - Drug Discovery Today, 2016 - Elsevier
… identified through high-throughput screens on GSK's proprietary libraries undergo optimization
… of better and more tolerable formulations. Repositioning also requires efforts to discover …
… of better and more tolerable formulations. Repositioning also requires efforts to discover …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
… chemistry tools have helped to optimize the therapeutic outcome (ie, … successfully via traditional
drug discovery approaches. … An additional portion of less “druggable” targets is those that …
drug discovery approaches. … An additional portion of less “druggable” targets is those that …
Challenges and Tools for In Vitro Leishmania Exploratory Screening in the Drug Development Process: An Updated Review
A Cohen, N Azas - Pathogens, 2021 - mdpi.com
… ,9] and, with the liposomal formulation that reduces the nephrotoxic side … The adaptation and
optimization of this approach for … a growing number of parasitic druggable targets in order to …
optimization of this approach for … a growing number of parasitic druggable targets in order to …
Targeted Protein Degraders-The druggability perspective
S Singh, P Srivastava - Journal of Pharmaceutical Sciences, 2023 - Elsevier
… To mitigate the stability-related challenges protective formulation design can be … stability
during storage. Additionally apposite formulation strategies could be established for optimization …
during storage. Additionally apposite formulation strategies could be established for optimization …
Knowledge gaps in generating cell-based drug delivery systems and a possible meeting with artificial intelligence
N Mozafari, N Mozafari, A Dehshahri… - Molecular …, 2023 - ACS Publications
… to optimize the successful formulation design and identify which candidate therapeutic agents
would have high drug loading, as well as to choosethe suitable formulation conditions for …
would have high drug loading, as well as to choosethe suitable formulation conditions for …
Niosomes: a novel targeted drug delivery system
I Akbarzadeh, K Sedaghatnia, M Bourbour… - 2021 - preprints.org
… , characterization, preparation methods, optimization with in-… to other ionic carriers, namely
liposomes. Niosomes are less … hide other potentially druggable sites because most proteins …
liposomes. Niosomes are less … hide other potentially druggable sites because most proteins …
[HTML][HTML] Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics
A Ulldemolins, J Seras-Franzoso, F Andrade… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
… expand the range of druggable targets, from proteins … liposomal NP for the treatment of
acute myeloid leukemia that incorporates the drugs cytarabine and daunorubicin in an optimized …
acute myeloid leukemia that incorporates the drugs cytarabine and daunorubicin in an optimized …