Nanopharmaceuticals to target antifilarials: administration of old age drugs in a novel way

N Joardar, N Mukherjee, SPS Babu - Applications of Nanobiotechnology …, 2021 - Elsevier
optimization for its bigger efficacy and better pharmacological attires [42]. Furthermore, through
… been made in the liposomal chemistry with the generation of stealth liposomes, targeted …

Discovery DMPK quick guide

SC Khojasteh, H Wong, D Zhang, C Hop - Guide to data interpretation and …, 2022 - Springer
… , we look through the lens of druggability by examining absorption, … Here, we focus on the
application of these concepts duringoptimization process with an emphasis on optimization of …

Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

MS Khan, BHJ Gowda, WH Almalki, T Singh… - Drug Discovery …, 2023 - Elsevier
… Therefore, further optimization of formulation parameters will … However, owing to a lack of
druggable targets, chemotherapy … The concept of using mitochondria-targeting liposomes for …

Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective

LG Ferreira, AD Andricopulo - Drug Discovery Today, 2016 - Elsevier
… identified through high-throughput screens on GSK's proprietary libraries undergo optimization
… of better and more tolerable formulations. Repositioning also requires efforts to discover …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
… chemistry tools have helped to optimize the therapeutic outcome (ie, … successfully via traditional
drug discovery approaches. … An additional portion of less “druggable” targets is those that …

Challenges and Tools for In Vitro Leishmania Exploratory Screening in the Drug Development Process: An Updated Review

A Cohen, N Azas - Pathogens, 2021 - mdpi.com
… ,9] and, with the liposomal formulation that reduces the nephrotoxic side … The adaptation and
optimization of this approach for … a growing number of parasitic druggable targets in order to …

Targeted Protein Degraders-The druggability perspective

S Singh, P Srivastava - Journal of Pharmaceutical Sciences, 2023 - Elsevier
… To mitigate the stability-related challenges protective formulation design can be … stability
during storage. Additionally apposite formulation strategies could be established for optimization

Knowledge gaps in generating cell-based drug delivery systems and a possible meeting with artificial intelligence

N Mozafari, N Mozafari, A Dehshahri… - Molecular …, 2023 - ACS Publications
… to optimize the successful formulation design and identify which candidate therapeutic agents
would have high drug loading, as well as to choosethe suitable formulation conditions for …

Niosomes: a novel targeted drug delivery system

I Akbarzadeh, K Sedaghatnia, M Bourbour… - 2021 - preprints.org
… , characterization, preparation methods, optimization with in-… to other ionic carriers, namely
liposomes. Niosomes are less … hide other potentially druggable sites because most proteins …

[HTML][HTML] Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics

A Ulldemolins, J Seras-Franzoso, F Andrade… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
… expand the range of druggable targets, from proteins … liposomal NP for the treatment of
acute myeloid leukemia that incorporates the drugs cytarabine and daunorubicin in an optimized