… (ED), oral phosphodiesterase type 5 inhibitors (PDE-5Is) are used worldwide with confirmed
efficacy, tolerability, and couple satisfaction. Eleven groups of PDE isoenzymes were …

… inhibition of PDE5 activity can achieve different favorable effects, and, therefore, different
clinical applications … of PDE5 together with the possible specific clinical application of PDE5i. …

… Phosphodiesterase type 5 inhibitors (PDE5Is), due to their efficacy and tolerable profile for
more than 2 decades,are considered a good … Oral PDE5Is have in general stimulatory effects …

… effects. Conclusion: Oral PDE5-Is are an eye-catching therapeutic class of agents with
beneficial effects for women, which could be potentially applied after well-designed clinical trials. …

… Nowadays, Oral phosphodiesterase type 5 inhibitors (PDE5Is) … Currently, four oral PDE5Is
have been approved by the US … , and avanafil with good efficacy and bearable adverse effects. …

… beneficial … PDE5 inhibitors tend to increase circulating testosterone levels somewhat. For
short-term exposure consistent with use prior to intercourse, there appears to be minimal effects …

… mechanism that explain the favorable effects of PDE5 inhibitors in these patients. Sildenafil
citrate use has been verified to exhibit protective effects in pulmonary arterial hypertension …

… Currently, oral phosphodiesterase type 5 inhibitors (PDE5Is) are the first-line therapy for
ED. However, they are effective in all treated cases with variable non-responsiveness. Many …

… enzyme, researchers have looked into further non-erectogenic and non-hypertensive uses …
are also multidrug resistance transporter inhibitors, it is possible that they will be helpful in the …

… In conclusion, we found that the PDE 5 inhibitor tadalafil has anti-nociceptive effects at different
… Oral phosphodiesterase-5 inhibitors: non-erectogenic beneficial uses. J Sex Med. 2008; …