[HTML][HTML] New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
L Zhang, LY Xu, F Tang, D Liu, XL Zhao… - Journal of …, 2024 - Elsevier
… In conclusion, Nrf2 activation plays a crucial role in protecting muscles from inflammation-induced
damage and oxidative stress. Nrf2 regulates mitochondrial function, cellular redox …
damage and oxidative stress. Nrf2 regulates mitochondrial function, cellular redox …
[HTML][HTML] Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease
V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
… studied in the disease contexts. This review aims to provide the reader with a general overview
of oxidative stress and Nrf2, including basic mechanisms of Nrf2 activation and regulation…
of oxidative stress and Nrf2, including basic mechanisms of Nrf2 activation and regulation…
Therapeutic modulation of virus‐induced oxidative stress via the Nrf2‐dependent antioxidative pathway
C Lee - Oxidative Medicine and Cellular Longevity, 2018 - Wiley Online Library
… In order to neutralize the deleterious effects of oxidative stress, mammalian cells established
a … However, upon encountering oxidative stress, an oxidant-sensitive molecule is activated …
a … However, upon encountering oxidative stress, an oxidant-sensitive molecule is activated …
Nrf2, a potential therapeutic target against oxidative stress in corneal diseases
XF Liu, DD Zhou, T Xie, TH Malik, CB Lu… - Oxidative medicine …, 2017 - Wiley Online Library
… therapeutic potential of EP in corneal wound healing [20]. Trichostatin A (TSA), a nonselective
inhibitor of histone deacetylase (HDAC), was revealed to possess the capacity for fibrosis …
inhibitor of histone deacetylase (HDAC), was revealed to possess the capacity for fibrosis …
Nrf2—a promising therapeutic target for defensing against oxidative stress in stroke
R Zhang, M Xu, Y Wang, F Xie, G Zhang, X Qin - Molecular Neurobiology, 2017 - Springer
… Keap1-Nrf2-ARE signaling, so here, we provide only a brief overview to provide the context
for our discussion of how Nrf2 protects brain tissue against oxidative stress in stroke. Nrf2 is …
for our discussion of how Nrf2 protects brain tissue against oxidative stress in stroke. Nrf2 is …
[HTML][HTML] Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
… evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, …
oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can …
oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can …
[HTML][HTML] The potential of Nrf2 activation as a therapeutic target in systemic lupus erythematosus
MT Barati, DJ Caster - Metabolites, 2022 - mdpi.com
… of studies have investigated Nrf2-inducing compounds in mouse models of SLE. These
studies highlighted the therapeutic potential of Nrf2 activation for decreasing oxidative stress and …
studies highlighted the therapeutic potential of Nrf2 activation for decreasing oxidative stress and …
[HTML][HTML] Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson's Disease
… Although causal relationships between oxidative damage and PD remain to be defined
fully, the evidence has shown that oxidative damage occurs in PD as indicated by oxidative …
fully, the evidence has shown that oxidative damage occurs in PD as indicated by oxidative …
Nrf2: a potential therapeutic target for diabetic neuropathy
A Kumar, R Mittal - Inflammopharmacology, 2017 - Springer
… Nrf2 in progression of diabetic neuropathy, targeting Nrf2 activators as a therapeutic potential
… , hyperglycemia leads to oxidative stress and results in changes in levels of nrf2. In acute …
… , hyperglycemia leads to oxidative stress and results in changes in levels of nrf2. In acute …
[HTML][HTML] Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
D Mondal, D Narwani, S Notta, D Ghaffar… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
… , we will discuss the therapeutic potential of a master regulator of oxidative stress, the Nrf2-transcription
factor and its antagonism of NF-κB, towards the resolution of oxidative stress and …
factor and its antagonism of NF-κB, towards the resolution of oxidative stress and …