[HTML][HTML] New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation

L Zhang, LY Xu, F Tang, D Liu, XL Zhao… - Journal of …, 2024 - Elsevier
… In conclusion, Nrf2 activation plays a crucial role in protecting muscles from inflammation-induced
damage and oxidative stress. Nrf2 regulates mitochondrial function, cellular redox …

[HTML][HTML] Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease

V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
… studied in the disease contexts. This review aims to provide the reader with a general overview
of oxidative stress and Nrf2, including basic mechanisms of Nrf2 activation and regulation…

Therapeutic modulation of virus‐induced oxidative stress via the Nrf2‐dependent antioxidative pathway

C Lee - Oxidative Medicine and Cellular Longevity, 2018 - Wiley Online Library
… In order to neutralize the deleterious effects of oxidative stress, mammalian cells established
a … However, upon encountering oxidative stress, an oxidant-sensitive molecule is activated

Nrf2, a potential therapeutic target against oxidative stress in corneal diseases

XF Liu, DD Zhou, T Xie, TH Malik, CB Lu… - Oxidative medicine …, 2017 - Wiley Online Library
therapeutic potential of EP in corneal wound healing [20]. Trichostatin A (TSA), a nonselective
inhibitor of histone deacetylase (HDAC), was revealed to possess the capacity for fibrosis …

Nrf2—a promising therapeutic target for defensing against oxidative stress in stroke

R Zhang, M Xu, Y Wang, F Xie, G Zhang, X Qin - Molecular Neurobiology, 2017 - Springer
… Keap1-Nrf2-ARE signaling, so here, we provide only a brief overview to provide the context
for our discussion of how Nrf2 protects brain tissue against oxidative stress in stroke. Nrf2 is …

[HTML][HTML] Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
… evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, …
oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can …

[HTML][HTML] The potential of Nrf2 activation as a therapeutic target in systemic lupus erythematosus

MT Barati, DJ Caster - Metabolites, 2022 - mdpi.com
… of studies have investigated Nrf2-inducing compounds in mouse models of SLE. These
studies highlighted the therapeutic potential of Nrf2 activation for decreasing oxidative stress and …

[HTML][HTML] Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson's Disease

M Ahuja, NA Kaidery, D Dutta, OC Attucks, EH Kazakov… - Antioxidants, 2022 - mdpi.com
… Although causal relationships between oxidative damage and PD remain to be defined
fully, the evidence has shown that oxidative damage occurs in PD as indicated by oxidative

Nrf2: a potential therapeutic target for diabetic neuropathy

A Kumar, R Mittal - Inflammopharmacology, 2017 - Springer
Nrf2 in progression of diabetic neuropathy, targeting Nrf2 activators as a therapeutic potential
… , hyperglycemia leads to oxidative stress and results in changes in levels of nrf2. In acute …

[HTML][HTML] Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators

D Mondal, D Narwani, S Notta, D Ghaffar… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
… , we will discuss the therapeutic potential of a master regulator of oxidative stress, the Nrf2-transcription
factor and its antagonism of NF-κB, towards the resolution of oxidative stress and …