… Loss of PTEN function in cancer cells (through a diversity of … leads to accumulation of PIP 3
and associated activation of AKT … -(3,4,5)-triphosphate (PIP 3 ) to generate PI(4,5)P 2 . PI3K, …

… In contrast to the role that PTEN and PIPP play in suppressing breast cancer progression,
the Src homology 2 (SH2) containing inositol 5-phosphatases, SHIP1 and SHIP2, show more …

… of PTEN function can have dramatic effects on cancer predisposition … cancer, PTEN function
can be compromised by a variety of mechanisms. In addition to genetic inactivation, PTEN …

… in PIK3CA or PTEN or both are associated with a higher risk of cervical cancer mortality and
tumor … Overall, the etiological role of HPV infection in cancer of the cervix has been greatly …

… in PTEN regulation and function, … loss of PTEN function is sufficient to promote tumor
development, and a 50% reduction in PTEN levels is associated with further acceleration of cancer …

… In this study, we describe the details of PTEN structure and function and the association
between various cancers associated with PTEN on the basis of a myriad of pertinent studies. …

… a high PTEN gene expression to be associated with worse prognosis for patients with breast
cancers harboring preserved p53 function. The finding that a high level of PTEN expression …

… Our results showed that the rate of PTEN loss was significantly higher in breast cancer tissues
than in matched normal tissues, which suggests that PTEN might play an important role in …

… For the secondary screen and the reanalysis in step 3, we used the one-sided Wilcoxon
rank-sum test (R function wilcox.test) for comparing ATARiS scores between two groups of cell …

… of PTEN and high CRISP3 expression are unfavorable indicators for prostate cancer, as
PTEN … BCR (P<0.001) and cancer-related mortalities (P=0.011). Using the combination of low …