… Panx1 (pannexin-1) channel and efflux of ATP from VSMCs. … receptors, thereby regulating
the effect of norepinehrine. This … attenuate α1-adrenergic receptor–mediated vasoconstriction. …

… Pannexin-1 opening is proposed to be mediated by α-adrenergic receptors to potentiate
sympathetic constriction… hypertensive patients and normotensive controls. We hypothesized that …

… Using a novel, inducible, VSMC-specific Cav1 knockout mouse, we also demonstrate that
Cav1 functionally regulates adrenergic-mediated ATP release, vasoconstriction, MAP, and …

… However, the molecular mechanisms regulating TRP channel activity in response to … in
response to α1-adrenergic stimulation and, consequently, in vasoconstrictive responses in the …

… receptors of the same or neighboring smooth muscle cells and strengthens their constriction
[… Notably, ectonucleotidases regulate the contraction of smooth muscle cells upon activation …

… constriction [46]. Activation of Panx1 occur by many mechanisms which include α1-adrenergic …
suggest that Pannexin 1 regulates synaptic plasticity and is required for proper learning. …

… of purinergic signaling in regulating renin secretion and renin … vasoconstriction responses
in resistance arteries and observed enhanced, phenylephrine-mediated vasoconstriction in …

… Because Panx1 can regulate α1-adrenergic receptor–mediated vasoconstriction and blood
pressure, 5 we assessed whether Panx1 may contribute to the antihypertensive effects of …

… Pannexin-1 function since mean arterial blood pressure and tyramine-… vasoconstriction
remain unaltered by Pannexin-1 inhibition after training in both groups. After training, Pannexin-1 …

… Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-adrenergic
receptor (α1-AR) vasoconstriction and … regulate phenylephrine-induced pannexin 1 …