… alterations (CNAs) has broad applications in cancer research. … One pair of tumor-normal
matched samples is picked from … using CLT that we call Deviation Binary Segmentation (DBS) …

… source software for estimating tumor purity, copy number, loss of … of tumor purity and ploidy,
even if matched normal samples … widely applicable, both in diagnostic and research settings. …

… circular binary segmentation CGH … novel bioinformatic solutions for copy number analysis
in cancer with these … alterations from NGS data were based on discordant read pairs. They are …

… The data set used in this thesis has a matched normal sample available for all tumor …
Parent-specific copy number in paired tumor–normal studies using circular binary segmentation…

… Oncogene activation and tumor suppressor gene inactivation … the average insert size between
the sequenced read-pairs … LNH-03B LYSA trials with available frozen tumor samples and …

… in cancer has gained much attention, but very few studies have … -paired tissue, whereas
methylation level for each cancer cell … number using circular binary segmentation algorithm as …

… segmentation algorithm used is circular binary segmentation (… ), matched tumor-normal pairs
(all three methods), and tumor-… of tumor heterogeneity in terms of absolute copy number and …

… A patient-matched normal sample or a reference pool of non-… binary segmentation40.
Segments are annotated with known … or gene, as previously reported in other studies47. The …

… Circular Binary Segmentation (CBS) estimates segment … by copy number alterations, and
is more suitable for cancer … the Parent-Specific CBS method 20 . Samples are then further …

… Previous research on genetic variations in prostate cancer … includes the parent-specific
circular binary segmentation (… copy number, to define segments in the dataset (23). For each …