Parkinson disease-induced upregulation of apoptotic mediators could be attenuated in the skeletal muscle following chronic exercise training
MD Al-Jarrah, NS Erekat - NeuroRehabilitation, 2017 - content.iospress.com
NeuroRehabilitation, 2017•content.iospress.com
BACKGROUND: We have shown elevated levels of p53 and active caspase-3 in
gastrocnemius skeletal muscle with Parkinson's disease (PD). The main aim of this study is
to examine the impact of endurance exercise training on the expression of p53 and active
caspase-3 in the skeletal muscle of mouse with induced Parkinsonism. METHODS:
Sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson
diseased (EPD) groups were formed; each consisting of 10 randomly selected normal albino …
gastrocnemius skeletal muscle with Parkinson's disease (PD). The main aim of this study is
to examine the impact of endurance exercise training on the expression of p53 and active
caspase-3 in the skeletal muscle of mouse with induced Parkinsonism. METHODS:
Sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson
diseased (EPD) groups were formed; each consisting of 10 randomly selected normal albino …
Abstract
BACKGROUND:
We have shown elevated levels of p53 and active caspase-3 in gastrocnemius skeletal muscle with Parkinson’s disease (PD). The main aim of this study is to examine the impact of endurance exercise training on the expression of p53 and active caspase-3 in the skeletal muscle of mouse with induced Parkinsonism.
METHODS:
Sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson diseased (EPD) groups were formed; each consisting of 10 randomly selected normal albino mice. Chronic Parkinson disease was induced in the SPD and EPD animals using 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine and probenecid (MPTP/p). The expression of p53 and active caspase-3 was investigated, using immunohistochemistry, in the gastrocnemius muscle in each animal group.
RESULTS:
Both p53 and active caspase-3 expression was significantly (p value< 0.05) reduced in the PD gastrocnemius skeletal muscle following endurance exercise training.
CONCLUSION:
Our present data suggest that chronic exercise training reduced Parkinson disease-induced upregulation of p53 and active caspase-3 in gastrocnemius skeletal muscle. Thus, our study suggests that inhibiting p53 and/or active caspase-3 may be considered as a therapeutic approach to ameliorate PD skeletal muscle abnormalities.
content.iospress.com
以上显示的是最相近的搜索结果。 查看全部搜索结果