Background Robust data on patient-reported outcome measures comparing treatments for
clinically localized prostate cancer are lacking. We investigated the effects of active
monitoring, radical prostatectomy, and radical radiotherapy with hormones on patient-
reported outcomes. Methods We compared patient-reported outcomes among 1643 men in
the Prostate Testing for Cancer and Treatment (ProtecT) trial who completed questionnaires
before diagnosis, at 6 and 12 months after randomization, and annually thereafter. Patients …

Editorial Comment: In this study of patient reported quality of life outcomes from the ProtecT
(Prostate Testing for Cancer and Treatment) trial the authors report 6-year outcomes of
questionnaire based urinary, sexual function, bowel and general health or cancer related
quality of life assessments. In the ProtecT trial 82,429 men 50 to 69 years old underwent
prostate specific antigen testing and those with a result greater than 3 ng/ml underwent
biopsy. Men with advanced disease at diagnosis were excluded, and those diagnosed with …