What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?

W Thevathasan, E Moro - Neurobiology of disease, 2019 - Elsevier
… ganglia – suggesting the PPN may influence or be influenced by higher order action selection…
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep

Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: a clinical review

…, Movement Disorders Society PPN DBS … - … Disorders, 2018 - Wiley Online Library
Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental
therapy for axial motor deficits in Parkinson's disease (… the increased REM sleep was a …

[HTML][HTML] A review of the pedunculopontine nucleus in Parkinson's disease

IT French, KA Muthusamy - Frontiers in Aging Neuroscience, 2018 - frontiersin.org
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral
portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear …

Role of pedunculopontine nucleus in sleep-wake cycle and cognition in humans: A systematic review of DBS studies

L Ricciardi, M Sarchioto, F Morgante - Neurobiology of Disease, 2019 - Elsevier
… of REM sleep time and REM percentage when PPN-DBS was ON compared to when the
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine

Pedunculopontine nucleus: an integrative view with implications on deep brain stimulation

A Nowacki, S Galati, J Ai-Schlaeppi, C Bassetti… - … of disease, 2019 - Elsevier
… in movement disorders such as Parkinson's disease (PD). … rates during wakefulness and
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …

[HTML][HTML] Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus

A Davin, S Chabardès, A Devergnas… - … Parkinson's Disease, 2023 - nature.com
stimulation (12 h of daytime stimulation) influencesREM sleep in the parkinsonian state;
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep

[HTML][HTML] Pedunculopontine nucleus degeneration contributes to both motor and non-motor symptoms of Parkinson's disease

NE Chambers, K Lanza, C Bishop - Frontiers in Pharmacology, 2020 - frontiersin.org
… Unfortunately, how PPN neuronal populations and their respective projections influence PD
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …

Pedunculopontine network dysfunction in Parkinson's disease with postural control and sleep disorders

C Gallea, C Ewenczyk, B Degos, ML Welter… - … Disorders, 2017 - Wiley Online Library
… to investigate pedunculopontine nucleus network dysfunctions … control and rapid eye
movement sleep behavior disorder (… processes is the SMA, which influences APA duration8 and is …

Deep brain stimulation of the pedunculopontine tegmental nucleus and arousal in Parkinson's disease

P Mazzone, G Della Marca, E Scarnati - … and Psychiatric Diseases, 2019 - Elsevier
… innervate midline thalamic nuclei, mediate REM sleep, and … -sleep stages in patients
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …

Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys

C Karachi, C Francois - Journal of Neural Transmission, 2018 - Springer
… in a position to influence thalamo-cortical activity, sleep–wakefulness states, … nuclei in the
regulation of arousal and REM sleep. Large PPN lesions in cats severely reduce REM sleep