What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?
W Thevathasan, E Moro - Neurobiology of disease, 2019 - Elsevier
… ganglia – suggesting the PPN may influence or be influenced by higher order action selection…
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep …
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep …
Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: a clinical review
…, Movement Disorders Society PPN DBS … - … Disorders, 2018 - Wiley Online Library
… Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental
therapy for axial motor deficits in Parkinson's disease (… the increased REM sleep was a …
therapy for axial motor deficits in Parkinson's disease (… the increased REM sleep was a …
[HTML][HTML] A review of the pedunculopontine nucleus in Parkinson's disease
IT French, KA Muthusamy - Frontiers in Aging Neuroscience, 2018 - frontiersin.org
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral
portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear …
portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear …
Role of pedunculopontine nucleus in sleep-wake cycle and cognition in humans: A systematic review of DBS studies
L Ricciardi, M Sarchioto, F Morgante - Neurobiology of Disease, 2019 - Elsevier
… of REM sleep time and REM percentage when PPN-DBS was ON compared to when the
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine …
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine …
Pedunculopontine nucleus: an integrative view with implications on deep brain stimulation
… in movement disorders such as Parkinson's disease (PD). … rates during wakefulness and
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …
[HTML][HTML] Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus
A Davin, S Chabardès, A Devergnas… - … Parkinson's Disease, 2023 - nature.com
… stimulation (12 h of daytime stimulation) influences … REM sleep in the parkinsonian state;
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep …
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep …
[HTML][HTML] Pedunculopontine nucleus degeneration contributes to both motor and non-motor symptoms of Parkinson's disease
NE Chambers, K Lanza, C Bishop - Frontiers in Pharmacology, 2020 - frontiersin.org
… Unfortunately, how PPN neuronal populations and their respective projections influence PD
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …
Pedunculopontine network dysfunction in Parkinson's disease with postural control and sleep disorders
… to investigate pedunculopontine nucleus network dysfunctions … control and rapid eye
movement sleep behavior disorder (… processes is the SMA, which influences APA duration8 and is …
movement sleep behavior disorder (… processes is the SMA, which influences APA duration8 and is …
Deep brain stimulation of the pedunculopontine tegmental nucleus and arousal in Parkinson's disease
… innervate midline thalamic nuclei, mediate REM sleep, and … -sleep stages in patients
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …
Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys
C Karachi, C Francois - Journal of Neural Transmission, 2018 - Springer
… in a position to influence thalamo-cortical activity, sleep–wakefulness states, … nuclei in the
regulation of arousal and REM sleep. Large PPN lesions in cats severely reduce REM sleep …
regulation of arousal and REM sleep. Large PPN lesions in cats severely reduce REM sleep …