… This review focuses on structural and biological aspects of perforin function. … and structural
insights of perforin have enhanced our collective understanding of how perforin interacts with …

… structure of membrane-inserted perforin pore at near-atomic resolution. In combination with
a previously solved crystal structure of the soluble perforin … to membrane insertion of perforin. …

… The perforin … perforin allele is Gnathostomata, or the jawed vertebrate. Earlier Chordata
species do not present with evidence of a perforin gene, despite possessing traditional perforin …

… and the lack of knowledge on perforin structure, alternative hypothesis of … perforin and
Gzms are endocytosed into endosomal compartments of target cells and subsequently perforin …

… Loss of perforin-2 renders individual … of perforin-2 activation and activity using atomic
structures of pre-pore and pore assemblies, high-speed atomic force microscopy, and functional …

… , previously suggested by comparison of their tertiary structures, can also be supported
by analyses of their primary structures. The superfamily includes the MACPF family (TC 1. C. …

… of toxoplasmosis and malaria, respectively, and use perforin-like proteins (PLPs) to invade
… We report structures of the membrane attack complex/perforin (MACPF) and Apicomplexan …

… homologues of perforin, … the structure and mechanism of pore formation by MACPF/CDC
proteins and then describe their distribution. Then we will focus on the structure and function of …

… perforin in medicine. The rationale of this article is to conduct further research about the role
and use of perforin … to motivate for further research and education about the role of perforin. …

… the structure of the majority endosomal region of ASTN-2, showing it to consist of a unique
combination of polypeptide folds: a perforin-… The perforin-like domain differs from that of other …