Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal …
T Abe, T Hosoi, R Kawai, N Uemura, E Higaki, B An… - Esophagus, 2019 - Springer
T Abe, T Hosoi, R Kawai, N Uemura, E Higaki, B An, J Kawakami, T Saito, Y Shimizu
Esophagus, 2019•SpringerBackground We clarified the effects of perioperative enteral supplementation with glutamine,
fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.
Methods Of 326 patients with esophageal cancer, 189 received GFO administration (GFO
group) and 137 did not (control group). The propensity score matching method was used to
identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters
and clinical and postoperative outcomes. Results The duration of the systemic inflammatory …
fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.
Methods Of 326 patients with esophageal cancer, 189 received GFO administration (GFO
group) and 137 did not (control group). The propensity score matching method was used to
identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters
and clinical and postoperative outcomes. Results The duration of the systemic inflammatory …
Background
We clarified the effects of perioperative enteral supplementation with glutamine, fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.
Methods
Of 326 patients with esophageal cancer, 189 received GFO administration (GFO group) and 137 did not (control group). The propensity score matching method was used to identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters and clinical and postoperative outcomes.
Results
The duration of the systemic inflammatory response syndrome (SIRS) was significantly shorter in the GFO group compared to the control group (p = 0.002). Moreover, the lymphocyte/neutrophil ratio (L/N ratio) had significantly recovered in the GFO group on postoperative day-3, and the CRP value was significantly lower in the GFO group than that in the control group on postoperative day-2.
Conclusions
Perioperative use of enteral supplementation with glutamine, fiber, and oligosaccharide likely contributes to a reduction in early surgical stress after an esophagectomy. These beneficial effects can bring about early recovery from postoperative immunosuppressive conditions after radical esophagectomy.
Springer
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