… delivery to the inner ear, choice of vectors, promoters, inner … in targeted tissues of the
inner ear without unwanted … cochlear explant cultures or into mouse inner ears by RWM or …

… Furthermore, 378 general limitation eg the mechanical properties of the utilized artificial
models compared to 379 that of inner ear tissue might confine the transferability of the results …

… Drugs injected directly into the perilymph of the inner ear are rapidly displaced by fluid
efflux at the injection site, resulting in inefficient and variable delivery. Fluid efflux can be …

… , potential routes of delivery into the inner ear, and, lastly, the … are much more tissue specific,
or only expressed at specific … /6N mouse, a mouse model of age-related hearing loss that …

… management into the pathologies of the inner ear using drug delivery system, also to review
… Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse. …

… properties of EVs specific to inner ear delivery. This review will … genetic materials targeting
inner ear cells or tissues, could … of MSC-EVs on hearing in a noise trauma mouse model. Their …

… option for inner ear gene delivery in a … in mouse models of hearing loss, larger animal
model studies are needed to ensure the efficacy of these approaches. In summary, gene delivery …

… Systematic delivery of OVs offers several advantages over IT … the collagen content of tumor
tissue. Furthermore, IT injection … to the control Ad vector in the mouse 4 T1 cell line and A549 …

… We utilized the helper dependent adenovirus vector, containing … were plated into 24-well
tissue culture plates at 1 × 10 4 cells/… in the mouse striatum, primary mouse dermal fibroblasts …

… 1 mouse model of dominant progressive hearing loss, we demonstrated the effective delivery
of RNP-EVs into inner ear … in the inner ear tissue for accessing and targeting inner ear cells …