… mouse with the use of an adenovirus vector has been … for pharmacokinetic and
pharmacodynamics studies of many … a very simple and practical mode of delivery, it is unknown if …

… optimal delivery and expression in the target cells or tissue and … of cells or tissues targeted
for gene delivery and treatment, … therapy was successfully demonstrated in mouse, rat, rabbit, …

… therapy trials is ensuring delivery to exclusively diseased … trial investigating the use of an
adenovirus vector to treat an x-… heart in vivo, we performed mouse biodistribution studies. Wild-…

… of tissue-specific Cre-driven knockout, our goal was to generate GS-knockout mice using local
delivery … than from crossing with a Cre-expressing mouse line was first described in 1995, …

… chromosomes of the cells or tissues that can be targeted to … Development of a recombinant
adenovirus vector production … delivered to mouse liver. J Virol 1998, 72, 2945–2954. 39. …

… Although pre-clinical and clinical testing of adenoviral vectors for vaccine delivery have …
Finally, adaptive immune responses against the adenovirus vector can develop in response …

… Preparing the mouse for insertion of the silicone window 79 2.3.3 Inserting a ventral … lung
tissue taken at autopsy has been used to confirm increased neutrophil infiltration into tissues …

… Adenovirus vector particles undergo multiple interactions … the most commonly used gene
delivery vehicles in molecular … correction of genetic defects in mouse models of human disease, …

… at gene therapy were inevitable. Development of the replication-deficient adenovirus vector
… or other molecules, and combined viral and lipid delivery strategies, are all discussed in Part …

… The pharmacodynamic study emphasized greater drug BA when dendrimers with …
been proposed for targeted transscleral delivery of therapeutic entities into ocular tissues [262]. …