Genetic Therapeutic Strategies for Bardet-Biedl Syndrome

MR Cring - 2020 - search.proquest.com
… in mouse models, and the results of my experiments can be used to direct future work aimed
atdelivery methods to introduce a functional copy of a gene to a patient. A more recent …

Available compounds with therapeutic potential against COVID-19: antimicrobial therapies, supportive care, and probable vaccines

R Kumar, JK Srivastava, R Singh… - … in pharmacology, 2020 - frontiersin.org
… activity in cell has not been reproduced in the mouse infection models for many viruses. Also,
… One such probable vaccine in the clinical trial stage is the recombinant adenovirus vector

Targeted Biological and Cellular Immunotherapies for Osteosarcoma

GM Robbins - 2023 - search.proquest.com
… Both allograft and xenograft cell line-derived mouse models … the pharmacokinetic and
pharmacodynamic profiles of drugs… deficient recombinant adenovirus vector and showed a …

Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

M Gerckens, K Schorpp, F Pelizza, M Wögrath… - Science …, 2021 - science.org
… Notably, a substantial number of proteins within this short list are related to tissuemouse
anti-collagen type 5 (1 mg/ml) from Sigma-Aldrich (catalog no. sc-166155), monoclonal mouse

HSV-1 infection in human induced pluripotent stem cell-derived neurons: Cellular models for quiescence and drug discovery

LL McClain - 2016 - search.proquest.com
… human sensory ganglia following primary infection through mucosal tissues. Once latent, the
virus … neural tissues that model aspects of latency are arguably well-suited for such screens. …

[PDF][PDF] TRESK background K+ channel deletion selectively uncovers enhanced mechanical

A Castellanos, A Pujol-Coma, A Andres-Bilbe, A Negm… - Neuron - core.ac.uk
Mouse tissue samples were obtained from dorsal root ganglia, kept in RNAlater … TRESK
gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from …

Friedreich ataxia: Treatment with genetic approach

M Nelwan - Journal of Advances in Biology & Biotechnology, 2017 - papers.ssrn.com
… later generation of adenovirus vector particles trigger quickly the innate invulnerable system
… gene delivery reverses genome instability in Friedreich ataxia patient and mouse model …

Disease modelling and treatment development for RCBTB1-associated retinopathy

E Huang - 2022 - research-repository.uwa.edu.au
… means gene augmentation therapy based on AAV delivery does not work for all the genes
[… the mouse iPSC-derived retinal tissue/sheets into the fully degenerated retina in mouse and …

Investigating viral subversion of intercellular communication

PJ Calhoun II - 2020 - vtechworks.lib.vt.edu
… the appropriate distribution of Cx43 gap junctions at intercalated … An adenovirus vector with
genetically modified fibers … human adenoviral vectors in mouse heart tissue which may not …

[PDF][PDF] Gene therapy with phosphodiesterases 2A and 4B in a murine model of pressure overload-induced cardiac hypertrophy

N Pavlaki - 2021 - ediss.sub.uni-hamburg.de
… , transgenic mouse lines were developed for biosensor expression in adult cardiac tissue/…
By overexpressing PDE2A3 and PDE4B3 in failing mouse hearts, we investigated the β-AR-…