Predicting the pharmacokinetics of piperacillin and tazobactam in preterm and term neonates using physiologically based pharmacokinetic modeling

JW Fisher, H Wu, M Cohen-Wolkowiez, K Watt… - Computational …, 2019 - Elsevier
… We are unaware of any studies with PAH in preterm neonates. In vitro studies with stably …
PIP and TAZ were obtained for 8 IV dosed preterm neonates with 4 more blood samples (…

[HTML][HTML] Drug disposition and pharmacotherapy in neonatal ECMO: from fragmented data to integrated knowledge

G Raffaeli, P Pokorna, K Allegaert, F Mosca… - Frontiers in …, 2019 - frontiersin.org
… in the field of neonatal pharmacology during ECMO. We will … midazolam as probe drug (67).
Such observations should be considered while prescribing drugs for critically ill neonates on …

From immature pharmacotherapy towards pharmacotherapy of the immature

K Allegaert, JN van den Anker - Seminars in Fetal and Neonatal Medicine, 2022 - Elsevier
Pharmacology suite, for preterm neonates from 24 weeks onwards. This model was subsequently
explored and tested based on intravenous … datasets on alfentanil, midazolam, caffeine, …

Clinical pharmacokinetics and pharmacodynamics of propofol

MM Sahinovic, MMRF Struys, AR Absalom - Clinical pharmacokinetics, 2018 - Springer
… It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …

Rifampin pharmacokinetics and safety in preterm and term infants

PB Smith, CM Cotten, ML Hudak… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
… of intravenous rifampin in infants of <121 days postnatal age (PNA). We enrolled 27 infants;
… However, as mentioned above, there are no specific PK/pharmacodynamic targets against S…

Developmental paediatric anaesthetic pharmacology

TG Hansen - Anaesthesia & Intensive Care Medicine, 2018 - Elsevier
… the increased permeability in preterm infants is short-lived, … in neonates means that onset
time after intravenous induction … in neonates and premature infants in whom midazolam is not …

[PDF][PDF] Clinical application of intravenous anesthetic infusion with use of a pharmacokinetic-pharmacodynamic model in children

희수김 - Anesthesia and Pain Medicine, 2017 - anesth-pain-med.org
… agents or sedatives (midazolam, dexmedetomidine). All these … pharmacodynamic models
for commonly used intravenous … Pharmacokinetic and pharmacodynamic study of midazolam

Midazolam as a first‐line treatment for neonatal seizures: Retrospective study

K Dao, E Giannoni, M Diezi… - Pediatrics …, 2018 - Wiley Online Library
… (2.8%): a preterm newborn with … preterm newborn who died on day 4, following grade IV
brain hemorrhage. In that case, death was attributed to brain hemorrhage and not to midazolam

O33 Towards personalised weaning of sedatives and analgesics using mechanism-based modelling of iatrogenic withdrawal in critically ill children

S Goulooze, E Krekels, M van Dijk, T Hankemeier… - 2019 - adc.bmj.com
… Morphine pharmacodynamics in mechanically ventilated preterm neonates undergoing …
The aim of the study was to investigate the pharmacokinetics of midazolam, after intravenous

Antibiotic Analgesic-Sedative and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

A Kontou, E Agakidou, I Chatziioannidis, W Chotas… - 2024 - preprints.org
… to inadequate studies in preterm infants include difficulties in … The use of midazolam as
sedative in ventilated infants is … gaps in knowledge in neonatal pharmacology and the need for …