Predicting the pharmacokinetics of piperacillin and tazobactam in preterm and term neonates using physiologically based pharmacokinetic modeling
JW Fisher, H Wu, M Cohen-Wolkowiez, K Watt… - Computational …, 2019 - Elsevier
… We are unaware of any studies with PAH in preterm neonates. In vitro studies with stably …
PIP and TAZ were obtained for 8 IV dosed preterm neonates with 4 more blood samples (…
PIP and TAZ were obtained for 8 IV dosed preterm neonates with 4 more blood samples (…
[HTML][HTML] Drug disposition and pharmacotherapy in neonatal ECMO: from fragmented data to integrated knowledge
G Raffaeli, P Pokorna, K Allegaert, F Mosca… - Frontiers in …, 2019 - frontiersin.org
… in the field of neonatal pharmacology during ECMO. We will … midazolam as probe drug (67).
Such observations should be considered while prescribing drugs for critically ill neonates on …
Such observations should be considered while prescribing drugs for critically ill neonates on …
From immature pharmacotherapy towards pharmacotherapy of the immature
K Allegaert, JN van den Anker - Seminars in Fetal and Neonatal Medicine, 2022 - Elsevier
… Pharmacology suite, for preterm neonates from 24 weeks onwards. This model was subsequently
explored and tested based on intravenous … datasets on alfentanil, midazolam, caffeine, …
explored and tested based on intravenous … datasets on alfentanil, midazolam, caffeine, …
Clinical pharmacokinetics and pharmacodynamics of propofol
MM Sahinovic, MMRF Struys, AR Absalom - Clinical pharmacokinetics, 2018 - Springer
… It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …
Rifampin pharmacokinetics and safety in preterm and term infants
… of intravenous rifampin in infants of <121 days postnatal age (PNA). We enrolled 27 infants;
… However, as mentioned above, there are no specific PK/pharmacodynamic targets against S…
… However, as mentioned above, there are no specific PK/pharmacodynamic targets against S…
Developmental paediatric anaesthetic pharmacology
TG Hansen - Anaesthesia & Intensive Care Medicine, 2018 - Elsevier
… the increased permeability in preterm infants is short-lived, … in neonates means that onset
time after intravenous induction … in neonates and premature infants in whom midazolam is not …
time after intravenous induction … in neonates and premature infants in whom midazolam is not …
[PDF][PDF] Clinical application of intravenous anesthetic infusion with use of a pharmacokinetic-pharmacodynamic model in children
희수김 - Anesthesia and Pain Medicine, 2017 - anesth-pain-med.org
… agents or sedatives (midazolam, dexmedetomidine). All these … pharmacodynamic models
for commonly used intravenous … Pharmacokinetic and pharmacodynamic study of midazolam …
for commonly used intravenous … Pharmacokinetic and pharmacodynamic study of midazolam …
Midazolam as a first‐line treatment for neonatal seizures: Retrospective study
… (2.8%): a preterm newborn with … preterm newborn who died on day 4, following grade IV
brain hemorrhage. In that case, death was attributed to brain hemorrhage and not to midazolam …
brain hemorrhage. In that case, death was attributed to brain hemorrhage and not to midazolam …
O33 Towards personalised weaning of sedatives and analgesics using mechanism-based modelling of iatrogenic withdrawal in critically ill children
S Goulooze, E Krekels, M van Dijk, T Hankemeier… - 2019 - adc.bmj.com
… Morphine pharmacodynamics in mechanically ventilated preterm neonates undergoing …
The aim of the study was to investigate the pharmacokinetics of midazolam, after intravenous …
The aim of the study was to investigate the pharmacokinetics of midazolam, after intravenous …
Antibiotic Analgesic-Sedative and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review
A Kontou, E Agakidou, I Chatziioannidis, W Chotas… - 2024 - preprints.org
… to inadequate studies in preterm infants include difficulties in … The use of midazolam as
sedative in ventilated infants is … gaps in knowledge in neonatal pharmacology and the need for …
sedative in ventilated infants is … gaps in knowledge in neonatal pharmacology and the need for …