… This potentially puts the preterm neonates at risk of receiving sub-… disposition and metabolism
in preterm neonates. We highlight … Midazolam is metabolized by CYP3A4 at a slower rate …

… of pharmacokinetic (PK), pharmacodynamic (PD), and safety … V d tends to be underpredicted
in preterm neonates; most … measurements of the V d of midazolam, it is known that V d is …

… in preterm infants as follows: 4 µmol/L for a preterm infant: 158 … from another study using
midazolam as the CYP3A probe … sildenafil iv Furthermore, oral absorption in preterm infants is …

… than 14 days, clonidine may facilitate weaning or transition from intravenous to oral therapy.
… Furthermore, there is a lack of pharmacokinetic data on DEX in preterm infants; therefore, …

… in vulnerable populations like preterm neonates. Although … occurs via inhalational or
intravenous routes, and other drug … clearance of levobupivacaine and midazolam and CYP1A2 for …

… for midazolam, alfentanil, caffeine, ibuprofen, gentamicin and vancomycin in preterm neonates
… Studies include single oral and intravenous (IV) doses of APAP as indicated and can be …

… drug pharmacokinetics and pharmacodynamics. Furthermore, … in term infants appears to be
different from preterm infants and … premature infants associated with midazolam intravenous …

… samples from preterm neonates and older infants during the first … %) after intravenous,
intramuscular and oral administration 14-… Midazolam and thiopental were used in most of the older …

… We report two neonates who developed epileptic manifestations a few seconds after the
bolus administration of intravenous midazolam. Other possible causes of seizures were ruled …

… It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …