[HTML][HTML] The blind spot of pharmacology: a scoping review of drug metabolism in prematurely born children
ML Mørk, JT Andersen, U Lausten-Thomsen… - … in Pharmacology, 2022 - frontiersin.org
… This potentially puts the preterm neonates at risk of receiving sub-… disposition and metabolism
in preterm neonates. We highlight … Midazolam is metabolized by CYP3A4 at a slower rate …
in preterm neonates. We highlight … Midazolam is metabolized by CYP3A4 at a slower rate …
[HTML][HTML] Feasibility of a pragmatic PBPK modeling approach: towards model-informed dosing in pediatric clinical care
JEM van der Heijden, JJM Freriksen… - Clinical …, 2022 - Springer
… of pharmacokinetic (PK), pharmacodynamic (PD), and safety … V d tends to be underpredicted
in preterm neonates; most … measurements of the V d of midazolam, it is known that V d is …
in preterm neonates; most … measurements of the V d of midazolam, it is known that V d is …
Physiologically‐based pharmacokinetic modeling characterizes the CYP3A‐mediated drug‐drug interaction between fluconazole and sildenafil in infants
SN Salerno, A Edginton, JG Gerhart… - … Pharmacology & …, 2021 - Wiley Online Library
… in preterm infants as follows: 4 µmol/L for a preterm infant: 158 … from another study using
midazolam as the CYP3A probe … sildenafil iv Furthermore, oral absorption in preterm infants is …
midazolam as the CYP3A probe … sildenafil iv Furthermore, oral absorption in preterm infants is …
The Use of Dexmedetomidine in Preterm Infants: A Single Academic Center Experience
J Guillen-Hernandez, KC Kyllonen… - … Pharmacology …, 2023 - meridian.allenpress.com
… than 14 days, clonidine may facilitate weaning or transition from intravenous to oral therapy.
… Furthermore, there is a lack of pharmacokinetic data on DEX in preterm infants; therefore, …
… Furthermore, there is a lack of pharmacokinetic data on DEX in preterm infants; therefore, …
Developmental pharmacology
G Wilson - Anaesthesia & Intensive Care Medicine, 2021 - Elsevier
… in vulnerable populations like preterm neonates. Although … occurs via inhalational or
intravenous routes, and other drug … clearance of levobupivacaine and midazolam and CYP1A2 for …
intravenous routes, and other drug … clearance of levobupivacaine and midazolam and CYP1A2 for …
Physiologically based pharmacokinetic modelling of acetaminophen in preterm neonates—The impact of metabolising enzyme ontogeny and reduced cardiac output
O Olafuyi, MY Abbasi, K Allegaert - Biopharmaceutics & Drug …, 2021 - Wiley Online Library
… for midazolam, alfentanil, caffeine, ibuprofen, gentamicin and vancomycin in preterm neonates
… Studies include single oral and intravenous (IV) doses of APAP as indicated and can be …
… Studies include single oral and intravenous (IV) doses of APAP as indicated and can be …
The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures: Single Center Experience and Literature Review
R Falsaperla, AD Collotta, V Sortino… - CNS & Neurological …, 2024 - ingentaconnect.com
… drug pharmacokinetics and pharmacodynamics. Furthermore, … in term infants appears to be
different from preterm infants and … premature infants associated with midazolam intravenous …
different from preterm infants and … premature infants associated with midazolam intravenous …
Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine
M Kokki, M Heikkinen, P Välitalo… - … pharmacology, 2017 - Wiley Online Library
… samples from preterm neonates and older infants during the first … %) after intravenous,
intramuscular and oral administration 14-… Midazolam and thiopental were used in most of the older …
intramuscular and oral administration 14-… Midazolam and thiopental were used in most of the older …
[HTML][HTML] Paradoxical reaction to midazolam in preterm neonates: A case series
MK Gupta, JA Mondkar, D Hegde - … of Indian Society of Critical Care …, 2018 - ncbi.nlm.nih.gov
… We report two neonates who developed epileptic manifestations a few seconds after the
bolus administration of intravenous midazolam. Other possible causes of seizures were ruled …
bolus administration of intravenous midazolam. Other possible causes of seizures were ruled …
[HTML][HTML] Clinical pharmacokinetics and pharmacodynamics of propofol
MM Sahinovic, MMRF Struys, AR Absalom - Clinical pharmacokinetics, 2018 - Springer
… It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …
resulted in it becoming the most commonly used intravenous anaesthetic for the past three …