Analgesia and Sedation

L Nantais-Smith, CJ Herrington… - … Pharmacology for the …, 2023 - books.google.com
… nervous system protected the newborn, especially the preterm infant, from experiencing pain.
In … and metabolism of intravenous midazolam in preterm infants. Clinical Pharmacology & …

Analgesics and sedatives in critically ill newborns and infants: the impact on long‐term neurodevelopment

RM Schiller, K Allegaert, M Hunfeld… - … Pharmacology, 2018 - Wiley Online Library
preterm neonates between 24 and 32 weeks’ gestational age. Despite the availability of
these PK data, intravenous … Concerning sedatives, direct links between midazolam exposure …

O35 Midazolam pharmacokinetics in children with obesity

C Gade, E Sverrisdóttir, K Dalhoff, J Sonne… - 2019 - adc.bmj.com
… Morphine pharmacodynamics in mechanically ventilated preterm neonates undergoing …
The aim of the study was to investigate the pharmacokinetics of midazolam, after intravenous

Population pharmacokinetics of sildenafil in extremely premature infants

D Gonzalez, MM Laughon, PB Smith… - … pharmacology, 2019 - Wiley Online Library
… sildenafil in premature infants following both intravenous and … PK in 2 cohorts of premature
infants; the first group was … received a single dose of intravenous (IV) sildenafil for the purpose …

[HTML][HTML] Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

L Buyssens, A Valenzuela, S Prims, M Ayuso… - … in Pharmacology, 2023 - frontiersin.org
preterm neonates, and several examples of adverse events due to immature DME have been
reported (eg, Grey baby … between GA and midazolam clearance in preterm neonates (32.8 …

Basics of paediatric anaesthetic pharmacology: a review based on practical challenges

SJS Bajwa, S Anand, H Gupta - Northern Journal of ISA, 2017 - ischolar.sscldl.in
… These pharmacodynamic alterations influence not only the … like midazolam in preterm and
newborn infants manifesting as … Intranasal midazolam compared with intravenous diazepam …

Midazolam as a first‐line treatment for neonatal seizures: Retrospective study

K Dao, E Giannoni, M Diezi… - Pediatrics …, 2018 - Wiley Online Library
… (2.8%): a preterm newborn with … preterm newborn who died on day 4, following grade IV
brain hemorrhage. In that case, death was attributed to brain hemorrhage and not to midazolam

Pharmacologic considerations of anesthetic agents in pediatric patients: a comprehensive review

AD Kaye, CJ Fox, IW Padnos… - Anesthesiology …, 2017 - anesthesiology.theclinics.com
… sedation with oral midazolam versus placebo. The investigators concluded that the use of
pharmacology of intravenous bolus and continuous infusion fentanyl use in preterm infants, …

[HTML][HTML] Metabolism and pharmacokinetics of morphine in neonates: A review

GM Pacifici - Clinics, 2016 - SciELO Brasil
… Clinical pharmacology of ibuprofen in preterm infants: A meta-… Clinical pharmacology of
analgesics in infants and the … and pharmacodynamics after continuous intravenous infusion of …

Innovative approaches and recent advances in the study of ontogeny of drug metabolism and transport

BD van Groen, K Allegaert, D Tibboel… - … clinical pharmacology, 2022 - Wiley Online Library
… , in which a child receives an oral or intravenous (IV) dose of a … In preterm neonates, the oral
bioavailability ranged from 67 to … also influence the oral bioavailability of midazolam. A study …