… Midazolam is one such drug metabolized mainly by hepatic hydroxylation (CYP 3A4) [98]. …
PKPD relationships have been described for IV midazolam in adults. EEG signals that were …

… onset time after IV induction is slower in neonates that in early … by an oral dose of 25 mg/kg
per day in preterm neonates at … Midazolam administered by the buccal surface is now more …

… hour IV or 3–5 mcg/kg 8-hourly orally. … Oral preparation has a bitter taste; nasal administration
is very irritant. • Active metabolite: 1-Oh-midazolam; clearance is reduced in preterm infants…

… and pharmacokinetic and pharmacodynamic properties, … midazolam differ mainly in their
durations of action and available routes of administration. In addition to the common intravenous…

… A higher P/A for per oral clearance (CLpo) when compared with intravenous CL for
midazolam and theophylline (two of the CYP3A substrates with both iv and PO) also suggests a …

… MAC for volatile agents at ages ranging from preterm neonates to adults. Note that … Oral
midazolam is commonly given as a premed at an oral dose of 0.3–0.5 mg/kg. IV midazolam is …

… Morphine pharmacodynamics in mechanically ventilated preterm neonates undergoing …
The aim of the study was to investigate the pharmacokinetics of midazolam, after intravenous …

… 2/ Cutaneous receptive fields are large in preterm neonates … Midazolam clearance in the
preterm infant is 1.8 mL/kg/min on … Clinical pharmacology of fentanyl in preterm infants. A review…

… , azithromycin, propofol, midazolam, lorazepam, and caffeine). … in preterm and term neonates
(p = 0.79 for preterm neonates … tings, switch from intravenous to oral antibiotics is important …

… on pharmacokinetics–pharmacodynamics in preterm infants are … of very preterm infants who
receive intravenous morphine … in use of midazolam with fewer infants receiving midazolam, …