Personalizing direct oral anticoagulant therapy for a diverse population: Role of race, kidney function, drug interactions, and pharmacogenetics
LE Thompson, BH Davis, R Narayan… - Clinical …, 2023 - Wiley Online Library
… DOACs have stable pharmacokinetics and pharmacodynamics; however, variability in
DOAC response is common and may be attributed to numerous factors, including patient‐specific …
DOAC response is common and may be attributed to numerous factors, including patient‐specific …
[HTML][HTML] Age and sex in drug development and testing for adults
C Tannenbaum, D Day - Pharmacological research, 2017 - Elsevier
… However, biological differences between the sexes other … Differences in PK, PD, and
pharmacogenomics have been … differences in pharmacokinetics and/or pharmacodynamics. …
pharmacogenomics have been … differences in pharmacokinetics and/or pharmacodynamics. …
[HTML][HTML] Pharmacogenetic Variants Associated with Fluoxetine Pharmacokinetics from a Bioequivalence Study in Healthy Subjects
CA Díaz-Tufinio, JA Palma-Aguirre… - Journal of Personalized …, 2023 - mdpi.com
… “Depression” references in scientific documents have increased exponentially since 1950, …
into pharmacogenetics in pharmacokinetic studies, considering pharmacogenetics as an …
into pharmacogenetics in pharmacokinetic studies, considering pharmacogenetics as an …
Sex and gender differences in the treatment of arterial hypertension
J Tamargo, R Caballero… - Expert review of clinical …, 2023 - Taylor & Francis
… scientific gaps and optimize the treatment of hypertension in … However, because the P
value for interaction between … differences between men and women refer to sex differences…
value for interaction between … differences between men and women refer to sex differences…
A review of clinical pharmacogenetics Studies in African populations
F Radouani, L Zass, Y Hamdi, J da Rocha… - Personalized …, 2020 - Taylor & Francis
… individuals, explored the interaction between candidate genes and … unexplained
pharmacokinetic/pharmacodynamic variation … are essential for accelerating scientific progress. …
pharmacokinetic/pharmacodynamic variation … are essential for accelerating scientific progress. …
[HTML][HTML] Gender differences in cardiovascular pharmacotherapy—the example of hypertension: a mini review
J Kalibala, A Pechere-Bertschi… - Frontiers in …, 2020 - frontiersin.org
… differences between males and females throughout the nephron. … Disparities may be
related to biological factors as well as … gender and PK as well as pharmacogenetics, that could …
related to biological factors as well as … gender and PK as well as pharmacogenetics, that could …
[HTML][HTML] The Sex–gender effects in the road to tailored botanicals
… of biological characteristics that define humans as female or … on their chemical structure,
pharmacokinetic properties of the single … Indeed, there are also pharmacodynamic interactions …
pharmacokinetic properties of the single … Indeed, there are also pharmacodynamic interactions …
Pharmacogenetic considerations for HIV treatment in different ethnicities: an update
M Neary, A Owen - Expert opinion on drug metabolism & toxicology, 2017 - Taylor & Francis
… Historically, pharmacogenetics research focused on its core … Drug–drug interactions
between the antiretrovirals in … provides a genetic basis for this difference between populations. …
between the antiretrovirals in … provides a genetic basis for this difference between populations. …
[HTML][HTML] Genetic polymorphisms associated with the pharmacokinetics, pharmacodynamics and adverse effects of olanzapine, aripiprazole and risperidone
P Soria-Chacartegui, G Villapalos-García… - Frontiers in …, 2021 - frontiersin.org
… 1 (ABCB1), are associated to differences in pharmacokinetics. The three … , among others,
and several studies found associations between polymorphisms in these genes and variations …
and several studies found associations between polymorphisms in these genes and variations …
Drug interactions and pharmacogenetics
F Lokiec - Side Effects of Medical Cancer Therapy: Prevention …, 2018 - Springer
… although pharmacodynamic interactions are the aim of this kind of association, pharmacokinetic
interactions … in the case of biologically potent drugs (growth factors, interferon). Loss of …
interactions … in the case of biologically potent drugs (growth factors, interferon). Loss of …